Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 6/20 | 0.43 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.42 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.39 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.39 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.39 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.39 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.39 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.39 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | RXRB | P28702 | 1/20 | 0.38 |
| ▸ | BCL2 | P10415 | 1/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5737996 | 0.76 | MAP2 (0.41) | MCL1GPR17RXRARXRBALDH1A1 | |
| SCHEMBL5215846 | 0.70 | JAK2 (0.39) | MCL1RXRARXRBKMT2AKDM4E | |
| SCHEMBL13376480 | 0.70 | ESR1 (0.52) | MCL1RXRARXRBCYP1A2GAA | |
| SCHEMBL5273891 | 0.69 | KDM4E (0.51) | MCL1GPR17PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL5272766 | 0.69 | PRKAB2 (0.41) | MCL1GPR17PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL5274062 | 0.67 | L3MBTL1 (0.42) | MCL1GPR17PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL5270273 | 0.67 | MAP2 (0.55) | MCL1PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL5299189 | 0.67 | PTGES (0.52) | MCL1RXRARXRBKMT2AKDM4E | |
| SCHEMBL20392122 | 0.67 | CYP1A2 (0.50) | MCL1RXRARXRBKMT2AMEN1 | |
| SCHEMBL5269262 | 0.67 | JAK2 (0.51) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765775-A1 | INDOLES USEFUL IN THE TREATMENT OF INFLAMMATION | Biolipox AB (SE) | 2007-03-28 | — | — | EP | disclosed |
| WO-2005123675-A1 | INDOLES USEFUL IN THE TREATMENT OF INFLAMMATION | BIOLIPOX AB (SE) | 2005-12-29 | — | — | WO | disclosed |