SCHEMBL5202198

SCHEMBL5202198

O=C(Cl)Cc1ccc(NS(=O)(=O)c2ccccc2)cc1

nearest known ligand 0.71

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 5/20 0.71
HDAC8 Q9BY41 3/20 0.71
HDAC4 P56524 1/20 0.59
HTR6 P50406 1/20 0.59
ALDH1A1 P00352 3/20 0.59
MEN1 O00255 3/20 0.59
KMT2A Q03164 3/20 0.59
PKM P14618 1/20 0.59
KEAP1 Q14145 2/20 0.58
IL1RN P18510 1/20 0.58
ERAP1 Q9NZ08 1/20 0.58
LMNA P02545 1/20 0.55
GAA P10253 1/20 0.54
PTGDR2 Q9Y5Y4 1/20 0.53
CA12 O43570 1/20 0.53
CA1 P00915 1/20 0.53
CA2 P00918 1/20 0.53
CA9 Q16790 1/20 0.53
AR P10275 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5205017 0.87 HDAC1 (0.75) HDAC1HDAC8HDAC4HTR6ALDH1A1
SCHEMBL397676 0.85 HDAC1 (0.68) HDAC1HDAC8HDAC4HTR6ALDH1A1
SCHEMBL14812106 0.83 HDAC8 (1.00) HDAC1HDAC8HDAC4HTR6ALDH1A1
SCHEMBL27889027 0.81 ALDH1A1 (0.67) HDAC1HDAC8HDAC4ALDH1A1MEN1
SCHEMBL2822371 0.80 MEN1 (0.67) HDAC1HDAC8HDAC4HTR6ALDH1A1
SCHEMBL810795 0.79 KMT2A (0.91) HTR6ALDH1A1MEN1KMT2APKM
SCHEMBL396740 0.79 HDAC1 (0.59) HDAC1HDAC8HDAC4HTR6ALDH1A1
SCHEMBL11107905 0.79 TBXA2R (0.64) HDAC8ALDH1A1MEN1KMT2AGAA
SCHEMBL11455802 0.79 ALDH1A1 (0.73) HDAC1HDAC8HDAC4HTR6ALDH1A1
SCHEMBL8249490 0.78 HDAC1 (0.76) HDAC1HDAC8HDAC4HTR6ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7160887-B1 Aromatic amine derivatives, their production and use TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-01-09 US disclosed
EP-1123918-B1 AROMATIC AMINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS CONTAINING THE SAME TAKEDA PHARMACEUTICAL (JP) 2005-03-09 EP disclosed
EP-1123918-A1 AROMATIC AMINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS CONTAINING THE SAME Takeda Chemical Industries, Ltd. (JP) 2001-08-16 EP disclosed