Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 10/20 | 0.32 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | NEK2 | P51955 | 1/20 | 0.31 |
| ▸ | FYN | P06241 | 2/20 | 0.31 |
| ▸ | REN | P00797 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5202421 | 0.90 | EGFR (0.33) | AAK1TP53NEK2FYNREN | |
| SCHEMBL5205418 | 0.89 | LMNA (0.36) | TP53KDM4EALDH1A1LMNAGAA | |
| SCHEMBL5201979 | 0.89 | LOXL2 (0.33) | TP53NEK2FYNRENKDM4E | |
| SCHEMBL5201228 | 0.89 | LOXL2 (0.33) | TP53NEK2FYNRENKDM4E | |
| SCHEMBL5200328 | 0.81 | HCRTR2 (0.35) | TP53NEK2KDM4EALDH1A1LMNA | |
| SCHEMBL5203311 | 0.71 | GAA (0.43) | FYNKDM4EALDH1A1GAASMN1; SMN2 | |
| SCHEMBL13813556 | 0.65 | PTGS2 (0.53) | ALDH1A1GAA | |
| SCHEMBL4109868 | 0.64 | FYN (0.50) | FYNALDH1A1GAA | |
| SCHEMBL4122811 | 0.64 | LOXL2 (0.53) | FYNALDH1A1GAALOXL2 | |
| SCHEMBL4120272 | 0.62 | GAA (0.46) | FYNKDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1400521-B1 | PIPERAZINE COMPOUNDS | KOWA CO (JP) | 2007-11-07 | — | — | EP | disclosed |
| EP-1400521-A1 | PIPERAZINE COMPOUNDS | Kowa Co., Ltd. (JP) | 2004-03-24 | — | — | EP | disclosed |
| US-6432957-B1 | ANTIASTHMA; ANTIALLERGENS; RHEUMATIC DISEASES; ANTIINFLAMMATORY AGENTS | KOWA CO., LTD. (JP) | 2002-08-13 | — | — | US | disclosed |