Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 7/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | UBE2N | P61088 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.32 |
| ▸ | NEK2 | P51955 | 1/20 | 0.32 |
| ▸ | CASR | P41180 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5202421 | 0.84 | EGFR (0.33) | TP53ALDH1A1KDM4ESMN1; SMN2LMNA | |
| SCHEMBL5201228 | 0.83 | LOXL2 (0.33) | TP53ALDH1A1KDM4ESMN1; SMN2LMNA | |
| SCHEMBL5201979 | 0.83 | LOXL2 (0.33) | TP53ALDH1A1KDM4ESMN1; SMN2LMNA | |
| SCHEMBL5202589 | 0.81 | AAK1 (0.32) | TP53ALDH1A1KDM4ESMN1; SMN2LMNA | |
| SCHEMBL5205418 | 0.80 | LMNA (0.36) | TP53ALDH1A1KDM4ESMN1; SMN2HPGD | |
| SCHEMBL5203311 | 0.75 | GAA (0.43) | ALDH1A1KDM4ESMN1; SMN2GAA | |
| SCHEMBL6787664 | 0.69 | DUT (0.30) | — | |
| SCHEMBL4109868 | 0.68 | FYN (0.50) | ALDH1A1GAASYK | |
| SCHEMBL4122811 | 0.68 | LOXL2 (0.53) | ALDH1A1GAASYKLOXL2 | |
| SCHEMBL13813556 | 0.66 | PTGS2 (0.53) | ALDH1A1GAASYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1400521-B1 | PIPERAZINE COMPOUNDS | KOWA CO (JP) | 2007-11-07 | — | — | EP | disclosed |
| EP-1400521-A1 | PIPERAZINE COMPOUNDS | Kowa Co., Ltd. (JP) | 2004-03-24 | — | — | EP | disclosed |
| US-6432957-B1 | ANTIASTHMA; ANTIALLERGENS; RHEUMATIC DISEASES; ANTIINFLAMMATORY AGENTS | KOWA CO., LTD. (JP) | 2002-08-13 | — | — | US | disclosed |