Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPSAB1 | Q15661 | 5/20 | 0.50 |
| ▸ | HRH2 | P25021 | 3/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 2/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5204500 | 0.92 | TPSAB1 (0.47) | TPSAB1HRH2KMT2ARORCCNR1 | |
| SCHEMBL5203872 | 0.80 | TPSAB1 (0.48) | TPSAB1HRH2HTR2AHTR2CHTR2B | |
| SCHEMBL5204533 | 0.78 | ALDH1A1 (0.46) | TPSAB1HRH2KMT2APROKR1 | |
| SCHEMBL5204952 | 0.77 | HRH2 (0.55) | TPSAB1HRH2HTR2AHTR2CHTR2B | |
| SCHEMBL4853030 | 0.77 | HDAC3 (0.46) | HRH2HTR2AHTR2CHTR2B | |
| SCHEMBL5204238 | 0.76 | HSD11B1 (0.47) | HTR2BKMT2A | |
| SCHEMBL5205803 | 0.76 | HRH2 (0.50) | TPSAB1HRH2HTR2AHTR2CHTR2B | |
| SCHEMBL4862667 | 0.75 | TSHR (0.47) | TPSAB1HRH2KMT2ACNR2PROKR1 | |
| SCHEMBL4862016 | 0.75 | SLC5A1 (0.49) | — | |
| SCHEMBL4859740 | 0.75 | HTR2A (0.46) | TPSAB1HRH2HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | claimed |