Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ2 | O43526 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.46 |
| ▸ | MGLL | Q99685 | 2/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.44 |
| ▸ | ITGAV | P06756 | 1/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2977727 | 0.86 | KIT (0.51) | KCNQ2TP53MAPTNPC1RAB9A | |
| SCHEMBL5200855 | 0.86 | MGLL (0.60) | KCNQ2TP53MAPTNPC1RAB9A | |
| SCHEMBL5211787 | 0.84 | KCNQ2 (0.62) | KCNQ2TP53MAPTNPC1RAB9A | |
| SCHEMBL5210446 | 0.83 | KCNQ2 (0.59) | KCNQ2TP53MAPTNPC1RAB9A | |
| SCHEMBL7908588 | 0.81 | KCNQ2 (0.57) | KCNQ2TP53MAPTNPC1RAB9A | |
| SCHEMBL2981606 | 0.78 | KIT (0.49) | MGLLJAK2ENPP2 | |
| SCHEMBL8985906 | 0.74 | SRD5A2 (0.60) | TP53MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5272080 | 0.74 | KCNQ2 (0.60) | KCNQ2MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2984996 | 0.73 | KCNQ2 (0.57) | KCNQ2ADORA2BADORA2A | |
| SCHEMBL8985820 | 0.72 | MMP13 (0.68) | KCNQ2TP53MAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831218-A2 | CARBAMATE SUBSTITUTED IMIDAZO- AND PYRROLO-PYRIDINES AS PROTEIN KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-09-12 | — | — | EP | claimed |
| WO-2006066914-A2 | CARBAMATE SUBSTITUTED IMIDAZO- AND PYRROLO-PYRIDINES AS PROTEIN KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-06-29 | — | — | WO | claimed |