Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.46 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5203496 | 0.85 | KMT2A (0.60) | KMT2AMEN1LMNAALDH1A1HTT | |
| SCHEMBL5202293 | 0.79 | THRB (0.49) | KMT2AMEN1LMNAALDH1A1KDM4E | |
| SCHEMBL5282265 | 0.79 | HCRTR1 (0.39) | KMT2AMEN1LMNAALDH1A1HTT | |
| SCHEMBL5204484 | 0.79 | SLC2A1 (0.47) | LMNAALDH1A1HTTNPSR1 | |
| SCHEMBL5203382 | 0.78 | MAPT (0.46) | KMT2AMEN1LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL4852934 | 0.77 | HRH2 (0.50) | KMT2ALMNAALDH1A1HTTNPC1 | |
| SCHEMBL5204486 | 0.76 | MAPT (0.54) | KMT2AMEN1LMNAALDH1A1HTT | |
| SCHEMBL4858756 | 0.76 | SLC2A1 (0.49) | KMT2AMEN1LMNAALDH1A1HTT | |
| SCHEMBL5205779 | 0.75 | HRH2 (0.49) | LMNAALDH1A1HTTTSHRSMN1; SMN2 | |
| SCHEMBL5203370 | 0.75 | HRH2 (0.47) | LMNAALDH1A1HTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | claimed |