Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 4/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5202929 | 0.79 | KMT2A (0.51) | TSHRGPBAR1LMNANPSR1MEN1 | |
| SCHEMBL5231721 | 0.77 | TSHR (0.51) | HCRTR1HCRTR2TSHRLMNAMEN1 | |
| SCHEMBL5203496 | 0.65 | KMT2A (0.60) | TSHRLMNAMEN1KMT2AGAA | |
| SCHEMBL4857642 | 0.64 | MAPT (0.41) | HCRTR1HCRTR2TSHRMEN1KMT2A | |
| SCHEMBL13732613 | 0.63 | ALDH1A1 (0.84) | TSHRGPBAR1LMNAMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL13733351 | 0.63 | ALDH1A1 (0.82) | TSHRGPBAR1LMNAMEN1KMT2A | |
| SCHEMBL5202293 | 0.60 | THRB (0.49) | LMNAMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL24480171 | 0.59 | LMNA (0.53) | LMNAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL5204486 | 0.59 | MAPT (0.54) | TSHRLMNANPSR1MEN1KMT2A | |
| SCHEMBL5432012 | 0.59 | ALDH1A1 (0.44) | LMNAMEN1KMT2AALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | disclosed |