Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.60 |
| ▸ | MEN1 | O00255 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 6/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 5/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5202929 | 0.85 | KMT2A (0.51) | KMT2AMEN1ALDH1A1NPC1EPAS1 | |
| SCHEMBL5231721 | 0.82 | TSHR (0.51) | KMT2AMEN1ALDH1A1NPC1EPAS1 | |
| SCHEMBL4862667 | 0.75 | TSHR (0.47) | KMT2AALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL5202510 | 0.75 | HSD11B1 (0.55) | KMT2AALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL12694150 | 0.74 | ALDH1A1 (0.70) | KMT2AMEN1ALDH1A1NPC1EPAS1 | |
| SCHEMBL12694217 | 0.74 | ALDH1A1 (0.70) | KMT2AMEN1ALDH1A1NPC1EPAS1 | |
| SCHEMBL5205358 | 0.73 | ALDH1A1 (0.45) | KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL5202100 | 0.72 | ALDH1A1 (0.51) | KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL5203757 | 0.72 | NPC1 (0.57) | KMT2AMEN1ALDH1A1NPC1KDM4E | |
| SCHEMBL5204500 | 0.72 | TPSAB1 (0.47) | KMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | claimed |