Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.36 |
| ▸ | AKT1 | P31749 | 4/20 | 0.36 |
| ▸ | AKT2 | P31751 | 3/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.36 |
| ▸ | AKT3 | Q9Y243 | 3/20 | 0.36 |
| ▸ | CNR1 | P21554 | 3/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5205537 | 0.86 | HDAC4 (0.42) | KMT2AMEN1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL5203070 | 0.78 | TACR2 (0.38) | KMT2AMEN1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL5202582 | 0.78 | MEN1 (0.38) | KMT2AMEN1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL5202845 | 0.77 | TRPV1 (0.40) | P2RX7CNR1CNR2DRD2 | |
| SCHEMBL4829888 | 0.77 | CNR1 (0.56) | KCNH2CNR1CNR2 | |
| SCHEMBL5203716 | 0.77 | OPRL1 (0.38) | KMT2AMEN1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL5203380 | 0.77 | HDAC4 (0.42) | SMN1; SMN2LMNATP53HDAC4SLC6A2 | |
| Hydrochloric Acid SCHEMBL4827960 | 0.76 | CNR1 (0.55) | KCNH2CNR1CNR2 | |
| SCHEMBL5200569 | 0.76 | TRPA1 (0.46) | SMN1; SMN2LMNAHDAC4SLC6A2SLC6A4 | |
| SCHEMBL5200534 | 0.76 | DRD2 (0.39) | KMT2AMEN1RAB9ASMN1; SMN2P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490043-A4 | SPIROCYCLIC AMIDES AS CANNABINOID RECEPTOR MODULATORS | MERCK & CO INC (US) | 2007-05-30 | — | — | EP | claimed |
| EP-1490043-A2 | SPIROCYCLIC AMIDES AS CANNABINOID RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2004-12-29 | — | — | EP | claimed |
| WO-2003082190-A2 | SPIROCYCLIC AMIDES AS CANNABINOID RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2003-10-09 | — | — | WO | claimed |