Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR2 | P21452 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5203716 | 0.99 | OPRL1 (0.38) | TACR2TACR1OPRL1SLC6A4SLC6A2 | |
| SCHEMBL5202986 | 0.78 | KMT2A (0.40) | SLC6A4SLC6A2TP53HDAC4SMN1; SMN2 | |
| SCHEMBL5205537 | 0.77 | HDAC4 (0.42) | SLC6A4SLC6A2ALDH1A1TP53HDAC4 | |
| SCHEMBL5202845 | 0.73 | TRPV1 (0.40) | GAA | |
| SCHEMBL5200534 | 0.71 | DRD2 (0.39) | SMN1; SMN2MEN1KMT2AGAARAB9A | |
| SCHEMBL5205476 | 0.69 | SLC6A2 (0.36) | SLC6A4SLC6A2ALDH1A1CYP2D6SLC6A3 | |
| SCHEMBL5266049 | 0.69 | RAB9A (0.60) | ALDH1A1TP53SMN1; SMN2MEN1KMT2A | |
| SCHEMBL4689271 | 0.68 | RAB9A (0.48) | ALDH1A1SMN1; SMN2MEN1KMT2AGAA | |
| SCHEMBL5202582 | 0.68 | MEN1 (0.38) | ALDH1A1TP53SMN1; SMN2MEN1KMT2A | |
| SCHEMBL5203380 | 0.68 | HDAC4 (0.42) | SLC6A4SLC6A2CYP2D6TP53SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490043-A4 | SPIROCYCLIC AMIDES AS CANNABINOID RECEPTOR MODULATORS | MERCK & CO INC (US) | 2007-05-30 | — | — | EP | disclosed |
| EP-1490043-A2 | SPIROCYCLIC AMIDES AS CANNABINOID RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003082190-A2 | SPIROCYCLIC AMIDES AS CANNABINOID RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2003-10-09 | — | — | WO | disclosed |