Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ITGB1 | P05556 | 10/20 | 0.38 |
| ▸ | ITGA4 | P13612 | 10/20 | 0.38 |
| ▸ | ITGB7 | P26010 | 2/20 | 0.36 |
| ▸ | GLS | O94925 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5201238 | 0.81 | ITGB1 (0.45) | MEN1RAB9AKMT2ASMN1; SMN2ITGB1 | |
| SCHEMBL5205537 | 0.79 | HDAC4 (0.42) | MEN1RAB9AKMT2ASMN1; SMN2P2RX7 | |
| SCHEMBL14064692 | 0.79 | CNR1 (0.50) | ITGB1ITGA4ITGB7 | |
| SCHEMBL4825568 | 0.79 | CNR1 (0.50) | ITGB1ITGA4ITGB7 | |
| SCHEMBL5202986 | 0.78 | KMT2A (0.40) | MEN1RAB9AKMT2ASMN1; SMN2P2RX7 | |
| SCHEMBL5480925 | 0.77 | PPARA (0.36) | MEN1RAB9AKMT2ASMN1; SMN2P2RX7 | |
| SCHEMBL5492414 | 0.76 | TP53 (0.43) | MEN1RAB9AKMT2ASMN1; SMN2P2RX7 | |
| SCHEMBL5203472 | 0.74 | RAB9A (0.38) | MEN1RAB9AKMT2ASMN1; SMN2P2RX7 | |
| SCHEMBL5200569 | 0.74 | TRPA1 (0.46) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL5203464 | 0.73 | ALDH1A1 (0.48) | MEN1RAB9AKMT2ASMN1; SMN2P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490043-A4 | SPIROCYCLIC AMIDES AS CANNABINOID RECEPTOR MODULATORS | MERCK & CO INC (US) | 2007-05-30 | — | — | EP | claimed |
| EP-1490043-A2 | SPIROCYCLIC AMIDES AS CANNABINOID RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2004-12-29 | — | — | EP | claimed |
| WO-2003082190-A2 | SPIROCYCLIC AMIDES AS CANNABINOID RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2003-10-09 | — | — | WO | claimed |