Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 9/20 | 0.45 |
| ▸ | ITGA4 | P13612 | 9/20 | 0.45 |
| ▸ | ITGB7 | P26010 | 9/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.34 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5200569 | 0.82 | TRPA1 (0.46) | SLC6A2SLC6A4SLC6A3ALDH1A1GPR139 | |
| SCHEMBL5202582 | 0.81 | MEN1 (0.38) | ITGB1ITGA4ITGB7ALDH1A1P2RX7 | |
| SCHEMBL4825610 | 0.80 | ITGB1 (0.56) | ITGB1ITGA4ITGB7CNR1 | |
| SCHEMBL5203380 | 0.77 | HDAC4 (0.42) | SLC6A2SLC6A4SLC6A3CNR1SMN1; SMN2 | |
| SCHEMBL5200440 | 0.76 | ALDH1A1 (0.48) | ITGA4ITGB7ALDH1A1P2RX7CNR1 | |
| SCHEMBL5202615 | 0.75 | ALDH1A1 (0.43) | ITGA4ITGB7ALDH1A1P2RX7CNR1 | |
| SCHEMBL5205537 | 0.74 | HDAC4 (0.42) | SLC6A2SLC6A4ALDH1A1P2RX7MEN1 | |
| SCHEMBL5202986 | 0.73 | KMT2A (0.40) | SLC6A2SLC6A4P2RX7CNR1MEN1 | |
| SCHEMBL5262774 | 0.72 | SLC6A9 (0.54) | SLC6A2SLC6A4SLC6A3P2RX7GPR139 | |
| SCHEMBL5480925 | 0.70 | PPARA (0.36) | SLC6A2SLC6A4SLC6A3ALDH1A1P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490043-A4 | SPIROCYCLIC AMIDES AS CANNABINOID RECEPTOR MODULATORS | MERCK & CO INC (US) | 2007-05-30 | — | — | EP | claimed |
| EP-1490043-A2 | SPIROCYCLIC AMIDES AS CANNABINOID RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2004-12-29 | — | — | EP | claimed |
| WO-2003082190-A2 | SPIROCYCLIC AMIDES AS CANNABINOID RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2003-10-09 | — | — | WO | claimed |
| EP-1490043-A4 | SPIROCYCLIC AMIDES AS CANNABINOID RECEPTOR MODULATORS | MERCK & CO INC (US) | 2007-05-30 | — | — | EP | disclosed |
| EP-1490043-A2 | SPIROCYCLIC AMIDES AS CANNABINOID RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003082190-A2 | SPIROCYCLIC AMIDES AS CANNABINOID RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2003-10-09 | — | — | WO | disclosed |