Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | HRH2 | P25021 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | PROKR1 | Q8TCW9 | 3/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5203433 | 0.92 | TPSAB1 (0.50) | TPSAB1KMT2ACRHR1CRHR2HRH2 | |
| SCHEMBL5204533 | 0.85 | ALDH1A1 (0.46) | TPSAB1KMT2AALDH1A1SMN1; SMN2HRH2 | |
| SCHEMBL4862667 | 0.82 | TSHR (0.47) | TPSAB1KMT2AALDH1A1SMN1; SMN2HRH2 | |
| SCHEMBL4853030 | 0.80 | HDAC3 (0.46) | ALDH1A1SMN1; SMN2HRH2MAPTHTR6 | |
| SCHEMBL5202510 | 0.80 | HSD11B1 (0.55) | TPSAB1KMT2AALDH1A1SMN1; SMN2HRH2 | |
| SCHEMBL5206419 | 0.80 | SMN1; SMN2 (0.49) | TPSAB1KMT2AALDH1A1SMN1; SMN2HRH2 | |
| SCHEMBL5204238 | 0.80 | HSD11B1 (0.47) | KMT2AALDH1A1SMN1; SMN2MAPTHTR6 | |
| SCHEMBL5202048 | 0.78 | SLC2A1 (0.44) | TPSAB1KMT2AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL5202100 | 0.78 | ALDH1A1 (0.51) | TPSAB1KMT2AALDH1A1SMN1; SMN2HRH2 | |
| SCHEMBL5202168 | 0.78 | PROKR1 (0.47) | TPSAB1KMT2AALDH1A1SMN1; SMN2HRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | claimed |
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | disclosed |