Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.54 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5204050 | 0.75 | ADRA1A (0.42) | ADRA2AADRA1AHRH3HRH4MAPT | |
| SCHEMBL5203578 | 0.75 | ADRA1A (0.53) | ADRA2AADRA1AHRH3HRH4TAAR1 | |
| SCHEMBL16882475 | 0.72 | HPGD (0.44) | CYP11B1CYP11B2LMNAMAPTCYP3A4 | |
| Oxalic Acid SCHEMBL5200567 | 0.71 | ADRA1A (0.38) | ADRA2AADRA1AHRH3HRH4MAPT | |
| SCHEMBL12865227 | 0.70 | TOP2A (0.50) | CYP11B1CYP11B2LMNAMAPTCYP3A4 | |
| SCHEMBL5204185 | 0.70 | HTR1D (0.49) | ADRA2AADRA1AHRH3TAAR1LMNA | |
| SCHEMBL12865204 | 0.69 | KEAP1 (0.50) | LMNAMAPTSMN1; SMN2PTGS1ALDH1A1 | |
| SCHEMBL3267511 | 0.69 | PTGS1 (0.50) | LMNAMAPTSMN1; SMN2PTGS1ALDH1A1 | |
| SCHEMBL5201429 | 0.68 | ADRA1A (0.48) | ADRA2AADRA1AHRH3HRH4TAAR1 | |
| SCHEMBL7595633 | 0.67 | LMNA (0.74) | LMNAMAPTSMN1; SMN2ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0887346-B1 | N-Phenyl-alkylsulfonamide derivatives, their preparation and their use as alpha1A/1L adrenoceptor agonists | HOFFMANN LA ROCHE (CH) | 2007-12-12 | — | — | EP | disclosed |