Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 11/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.73 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA4 | P22748 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | CA5A | P35218 | 1/20 | 0.49 |
| ▸ | CA7 | P43166 | 1/20 | 0.49 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 2/20 | 0.48 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.47 |
| ▸ | HTR3B | O95264 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | NCF1 | P14598 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31060240 | 0.84 | PRKDC (1.00) | PRKDCALDH1A1CA12CA1NQO1 | |
| SCHEMBL11450752 | 0.83 | PRKDC (1.00) | PRKDCALDH1A1 | |
| SCHEMBL30507300 | 0.83 | PRKDC (1.00) | PRKDCALDH1A1 | |
| SCHEMBL15068454 | 0.77 | ALDH1A1 (0.66) | PRKDCALDH1A1CA12CA1MAOB | |
| SCHEMBL30507414 | 0.76 | PRKDC (0.64) | PRKDCALDH1A1NQO1 | |
| SCHEMBL5476610 | 0.76 | PRKDC (0.71) | PRKDCALDH1A1MTOR | |
| SCHEMBL3560946 | 0.74 | HTR6 (0.53) | ALDH1A1HTR6HTR3EHTR3BCYP1A2 | |
| SCHEMBL30507579 | 0.74 | PRKDC (0.61) | PRKDCALDH1A1 | |
| SCHEMBL722215 | 0.74 | BACE1 (0.55) | ALDH1A1MAOBHTR6HTR3EHTR3B | |
| SCHEMBL30507534 | 0.73 | PRKDC (0.60) | PRKDCALDH1A1MAOBHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312210-B2 | Pyrrolo[2,1-c][1,4]benzodiazepine compounds and processes for the preparation thereof | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2007-12-25 | — | — | US | claimed |
| US-20070082891-A1 | Novel pyrrolo[2,1-C] [1,4] benzodiazepine compounds and processes for the preparation thereof | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2007-04-12 | — | — | US | claimed |
| CN-117024442-A | Targeting lysosomes, pH activated SO 2 Fluorescent probe and preparation and application thereof | 广东工业大学 | 2023-11-10 | — | — | CN | disclosed |
| US-7312210-B2 | Pyrrolo[2,1-c][1,4]benzodiazepine compounds and processes for the preparation thereof | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2007-12-25 | — | — | US | disclosed |
| WO-2007054954-A1 | A NOVEL PYRROLO[2,1-C][1,4]BENZODIAZEPINE HYBRID AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2007-05-18 | — | — | WO | disclosed |
| US-20070082891-A1 | Novel pyrrolo[2,1-C] [1,4] benzodiazepine compounds and processes for the preparation thereof | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2007-04-12 | — | — | US | disclosed |
| EP-0998474-B1 | PIPERAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2007-02-07 | — | — | EP | disclosed |
| CN-1093127-C | Piperazine derivatives | MERCK PATENT GMBH (DE) | 2002-10-23 | — | — | CN | disclosed |
| US-6251908-B1 | Piperazine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2001-06-26 | — | — | US | disclosed |
| CN-1264379-A | Piperazine derivatives | MERCK PATENT GMBH (DE) | 2000-08-23 | — | — | CN | disclosed |
| EP-0998474-A1 | PIPERAZINE DERIVATIVES | MERCK PATENT GmbH (DE) | 2000-05-10 | — | — | EP | disclosed |
| WO-1999003855-A1 | PIPERAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 1999-01-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070082891-A1 | Novel pyrrolo[2,1-C] [1,4] benzodiazepine compounds and processes for the preparation thereof | GABRA1, GABRA4, GABRA2 | PRKDC 3663/4885ALDH1A1 528/4885KDR 2380/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.