SCHEMBL5204298

SCHEMBL5204298

CC(=O)NC[C@H]1CN(c2cc(F)c(N3CCS(=O)(=O)CC3)c(F)c2)C(=O)O1

nearest known ligand 0.61

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
MAOA P21397 6/20 0.61
MAOB P27338 3/20 0.60
PTGS1 P23219 2/20 0.60
SDHA P31040 2/20 0.60
LMNA P02545 1/20 0.60
CALML3 P27482 1/20 0.60
F10 P00742 4/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5204305 0.92 MAOA (0.60) MAOAMAOBPTGS1SDHALMNA
SCHEMBL5240102 0.92 MAOA (0.60) MAOAMAOBPTGS1SDHALMNA
SCHEMBL23833823 0.91 F10 (0.56) MAOAMAOBPTGS1SDHALMNA
SCHEMBL27252753 0.90 F10 (0.54) MAOAMAOBPTGS1SDHALMNA
SCHEMBL23847765 0.90 F10 (0.54) MAOAMAOBPTGS1SDHALMNA
SCHEMBL18410708 0.90 MAOA (0.62) MAOAMAOBPTGS1SDHALMNA
SCHEMBL22698503 0.89 MAOA (0.58) MAOAMAOBPTGS1SDHALMNA
SCHEMBL3207960 0.88 MAOA (0.62) MAOAMAOBPTGS1SDHALMNA
SCHEMBL8308403 0.88 MAOA (0.76) MAOAMAOBPTGS1SDHALMNA
SCHEMBL3207948 0.88 MAOA (0.62) MAOAMAOBPTGS1SDHALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 85 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9795601-B2 Compositions and methods for cancer treatment BIOVISTA, INC. (US) 2017-10-24 US claimed
US-20130259800-A1 COMPOSITIONS AND METHODS FOR CANCER TREATMENT BIOVISTA, INC. (US) 2013-10-03 US claimed
US-6989381-B2 Solution composition of an oxazolidinone antibiotic drug having enhanced drug loading PHARMACIA CORPORATION (US) 2006-01-24 US claimed
EP-1311296-B1 SOLUTION OF AN OXAZOLIDINONE ANTIBIOTIC DRUG PHARMACIA CORP (US) 2005-12-14 EP claimed
EP-1294717-B1 A THIAZINE OXAZOLIDINONE PHARMACIA & UPJOHN CO LLC (US) 2005-12-07 EP claimed
US-20040191326-A1 Taste-masking vehicle for coated oxazolidinone particles REO JOSEPH P (US) 2004-09-30 US claimed
EP-1406880-A1 CRYSTALLINE THIAZINE OXAZOLIDINONES PHARMACIA & UPJOHN COMPANY (US) 2004-04-14 EP claimed
US-6696426-B2 SUITABLE FOR TOPICAL ADMINISTRATION TO EYE FOR THERAPY OR PROPHYLAXIS OF EYE INFECTIONS DUE TO GRAM POSITIVE BACTERIA PHARMACIA CORPORATION 2004-02-24 US claimed
US-20040019012-A1 Ophthalmic antibiotic drug formulations containing a cyclodextrin compound and cetyl pyridinium chloride PHARMACIA CORPORATION 2004-01-29 US claimed
US-20030232089-A1 Ophthalmic formulation with novel gum composition PHARMACIA CORPORATION 2003-12-18 US claimed
US-6551584-B2 Oxazolidinone antibacterial drug, for example linezolid, in a concentration effective for treatment or prophylaxis of a grampositive bacterial infection of an eye PHARMACIA & UPJOHN COMPANY 2003-04-22 US claimed
EP-1294717-A2 A THIAZINE OXAZOLIDINONE PHARMACIA & UPJOHN COMPANY (US) 2003-03-26 EP claimed
US-20030027790-A1 Preservative free ophthalmic oxazolidinone antibiotic drug delivery systems PHARMACIA CORPORATION 2003-02-06 US claimed
WO-2003006441-A1 CRYSTALLINE THIAZINE OXAZOLIDINONES PHARMACIA & UPJOHN COMPANY (US) 2003-01-23 WO claimed
US-20030008012-A1 Composition for rectal delivery of an oxazolidinone antibacterial drug PHARMACIA & UPJOHN COMPANY 2003-01-09 US claimed
US-20020156072-A1 Thiazine oxazolidinone PHARMACIA & UPJOHN COMPANY 2002-10-24 US claimed
US-20020107238-A1 Topical antibiotic composition for treatment of eye infection PHARMACIA & UPJOHN COMPANY 2002-08-08 US claimed
US-20020068720-A1 Solution composition of an oxazolidinone antibiotic drug having enhanced drug loading PHARMACIA CORPORATION 2002-06-06 US claimed
WO-2002030395-A1 TOPICAL ANTIBIOTIC COMPOSITION FOR TREATMENT OF EYE INFECTION PHARMACIA & UPJOHN COMPANY (US) 2002-04-18 WO claimed
WO-2001098297-A2 A THIAZINE OXAZOLIDINONE PHARMACIA & UP JOHN COMPANY (US) 2001-12-27 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030232089-A1 Ophthalmic formulation with novel gum composition PDE6C, PDE6A, PDE6H MAOA 1312/4885MAOB 1165/4885PTGS1 696/4885
US-20020156072-A1 Thiazine oxazolidinone OXA1L, TLR5, TALDO1 MAOA 2596/4885MAOB 2433/4885PTGS1 3145/4885
US-20040191326-A1 Taste-masking vehicle for coated oxazolidinone particles SORD, OXA1L, TAS2R20 MAOA 3161/4885MAOB 3076/4885PTGS1 4613/4885
US-20030027790-A1 Preservative free ophthalmic oxazolidinone antibiotic drug delivery systems PDCD2L, TBCD, OXA1L MAOA 4089/4885MAOB 4340/4885PTGS1 3102/4885
US-20130259800-A1 COMPOSITIONS AND METHODS FOR CANCER TREATMENT BRAF, ERBB3, ERBB2 MAOA 554/4885MAOB 219/4885PTGS1 2512/4885
US-20030008012-A1 Composition for rectal delivery of an oxazolidinone antibacterial drug MSH2, MCRS1, CUTA MAOA 187/4885MAOB 1770/4885PTGS1 3483/4885
US-20020107238-A1 Topical antibiotic composition for treatment of eye infection CUTA, DEK, LPXN MAOA 1172/4885MAOB 1818/4885PTGS1 2187/4885
US-20040019012-A1 Ophthalmic antibiotic drug formulations containing a cyclodextrin compound and cetyl pyridinium chloride PDCD2L, DSC1, TBCD MAOA 3992/4885MAOB 4044/4885PTGS1 4292/4885
US-20020068720-A1 Solution composition of an oxazolidinone antibiotic drug having enhanced drug loading ABCB11, SLC47A1, TBCD MAOA 3908/4885MAOB 3598/4885PTGS1 3767/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.