SCHEMBL520439

SCHEMBL520439

Nc1ccc(N2CCOCC2)cc1F

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LGMN Q99538 3/20 0.67
PLK4 O00444 1/20 0.49
MAPT P10636 6/20 0.48
ALOX15 P16050 3/20 0.48
SMN1; SMN2 Q16637 3/20 0.48
NPC1 O15118 2/20 0.48
RAB9A P51151 2/20 0.48
TP53 P04637 2/20 0.48
ALDH1A1 P00352 5/20 0.46
HTT P42858 5/20 0.46
MEN1 O00255 3/20 0.46
KMT2A Q03164 3/20 0.46
CYP1A2 P05177 1/20 0.46
LMNA P02545 5/20 0.46
KDM4E B2RXH2 3/20 0.44
MAPK1 P28482 3/20 0.44
USP2 O75604 1/20 0.44
HSD17B10 Q99714 1/20 0.44
HDAC3 O15379 1/20 0.44
HDAC4 P56524 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17265646 0.87 MAPT (0.52) LGMNMAPTALOX15SMN1; SMN2ALDH1A1
SCHEMBL29710195 0.86 LGMN (0.62) LGMNMAPTALOX15SMN1; SMN2NPC1
SCHEMBL2087889 0.86 LGMN (0.62) LGMNMAPTALOX15SMN1; SMN2NPC1
SCHEMBL3376365 0.83 ALDH1A1 (0.56) LGMNMAPTALOX15SMN1; SMN2NPC1
SCHEMBL22289269 0.83 ALDH1A1 (0.61) LGMNMAPTALOX15NPC1RAB9A
SCHEMBL904452 0.83 LGMN (0.73) LGMNMAPTALOX15SMN1; SMN2NPC1
SCHEMBL1127082 0.81 ALDH1A1 (0.65) LGMNMAPTALOX15NPC1RAB9A
SCHEMBL22716931 0.80 LGMN (1.00) LGMNMAPTALOX15SMN1; SMN2NPC1
SCHEMBL2376896 0.79 LGMN (0.49) LGMNMAPTALOX15SMN1; SMN2NPC1
SCHEMBL17742335 0.79 LGMN (0.67) LGMNMAPTALOX15SMN1; SMN2NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 111 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4656249-A2 PYRAZOLOPYRIMIDINE DERIVATIVES AS KINASE INHIBITOR Daewoong Pharmaceutical Co., Ltd. (KR) 2025-12-03 EP disclosed
US-12479845-B2 Imidazopyridine derivative compounds and use of same HANMI PHARM. CO., LTD. (KR) 2025-11-25 US disclosed
CN-113365996-B Imidazole pyridine derivative compound and pharmaceutical composition 韩美药品株式会社 2024-09-03 CN disclosed
EP-3478687-B1 PYRAZOLOPYRIMIDINE DERIVATIVES AS KINASE INHIBITOR DAEWOONG PHARMACEUTICAL CO LTD (KR) 2024-03-20 EP disclosed
EP-4327884-A2 1,4-DIHYDROBENZO[D]PYRAZOLO[3,4-F][1,3]DIAZEPINE DERIVATIVES AND RELATED COMPOUNDS AS LRRK2, NUAK1 AND/OR TYK2 KINASE MODULATORS FOR THE TREATMENT OF E.G. AUTOIMMUNE DISEASES Origenis GmbH (DE) 2024-02-28 EP disclosed
CN-111217816-B FLT3 kinase inhibitor and preparation and application thereof 中国科学院上海药物研究所 2022-08-16 CN disclosed
US-20220098205-A1 IMIDAZOPYRIDINE DERIVATIVE COMPOUNDS AND USE OF SAME HANMI PHARM. CO., LTD. (KR) 2022-03-31 US disclosed
EP-3950691-A1 PYRAZOLOPYRIMIDINE DERIVATIVES AS KINASE INHIBITOR Daewoong Pharmaceutical Co., Ltd. (KR) 2022-02-09 EP disclosed
WO-2022011274-A1 SUBSTITUTED 1,6-NAPHTHYRIDINE INHIBITORS OF CDK5 GOLDFINCH BIO, INC. (US) 2022-01-13 WO disclosed
EP-3640247-B1 SYK INHIBITOR AND USE METHOD THEREFOR CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD (CN) 2022-01-12 EP disclosed
US-6548512-B1 Pyrazole derivatives such as 1-(3-amidinophenyl)-3-methyl-2-((5-(2'-aminosulfonylphenyl-1-yl)pyrimidin-2 -yl)aminocarbonyl)pyrazole; treating thromboembolic disorders BRISTOL-MYERS SQUIBB PHARMA COMPANY 2003-04-15 US disclosed
US-20030069258-A1 Novel guanidine mimics factor Xa inhibitors BRISTOL-MYERS SQUIBB PHARMA COMPANY 2003-04-10 US disclosed
US-20020025963-A1 Novel guanidine mimics as factor Xa inhibitors BRISTOL-MYERS SQUIBB PHARMA COMPANY 2002-02-28 US disclosed
US-6339099-B1 FOR THERAPY AND PROPHYLAXIS OF THROMBOEMBOLIC DISORDER DUPONT PHARMACEUTICALS COMPANY 2002-01-15 US disclosed
EP-0991638-A1 NOVEL GUANIDINE MIMICS AS FACTOR Xa INHIBITORS Du Pont Pharmaceuticals Company (US) 2000-04-12 EP disclosed
CN-1246847-A Nitrogen containing heteroaromatics as factor Xa inhibitors DU PONT MERCK PHARMA (US) 2000-03-08 CN disclosed
US-6020357-A CARDIOVASCULAR DISORDERS; ANTCOAGULANTS DUPONT PHARMACEUTICALS COMPANY (US) 2000-02-01 US disclosed
EP-0946508-A1 NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS Du Pont Pharmaceuticals Company (US) 1999-10-06 EP disclosed
WO-1998057951-A1 NOVEL GUANIDINE MIMICS AS FACTOR Xa INHIBITORS DU PONT PHARMACEUTICALS COMPANY (US) 1998-12-23 WO disclosed
WO-1998028269-A1 NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS DU PONT PHARMACEUTICALS COMPANY (US) 1998-07-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220098205-A1 IMIDAZOPYRIDINE DERIVATIVE COMPOUNDS AND USE OF SAME KDM1A, KDM1B, KDM2A LGMN 2604/4885PLK4 1463/4885MAPT 251/4885
US-20030069258-A1 Novel guanidine mimics factor Xa inhibitors TFPI, F11, F12 LGMN 557/4885PLK4 4054/4885MAPT 4607/4885
US-12479845-B2 Imidazopyridine derivative compounds and use of same KDM1A, KDM1B, KDM2A LGMN 2604/4885PLK4 1463/4885MAPT 251/4885
US-20020025963-A1 Novel guanidine mimics as factor Xa inhibitors F11, SERPINC1, TFPI LGMN 384/4885PLK4 4034/4885MAPT 4566/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.