SCHEMBL5204516

SCHEMBL5204516

Cc1cc(-c2c(Cl)ccc(C(=O)c3cnn(C)c3O)c2Cl)on1

nearest known ligand 0.35

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.35
KDM4E B2RXH2 1/20 0.35
USP2 O75604 1/20 0.35
TSHR P16473 1/20 0.35
PRKAG1 P54619 1/20 0.34
PRKAA1 Q13131 1/20 0.34
PRKAB1 Q9Y478 1/20 0.34
NTRK1 P04629 1/20 0.34
CSF1R P07333 6/20 0.33
HPGD P15428 1/20 0.32
TP53 P04637 2/20 0.31
SMN1; SMN2 Q16637 2/20 0.31
KMT2A Q03164 3/20 0.31
MAPK1 P28482 2/20 0.30
MEN1 O00255 1/20 0.30
LMNA P02545 1/20 0.30
MAPT P10636 1/20 0.30
HTT P42858 1/20 0.30
HSD17B10 Q99714 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8712680 0.89 MEN1 (0.34) ALDH1A1KDM4EUSP2TSHRCSF1R
SCHEMBL2215157 0.87 CSF1R (0.33) ALDH1A1KDM4EUSP2TSHRPRKAG1
SCHEMBL8306233 0.86 SMN1; SMN2 (0.39) ALDH1A1KDM4EUSP2TSHRPRKAG1
SCHEMBL27464247 0.85 KDM4E (0.31) ALDH1A1KDM4EUSP2TSHRCSF1R
SCHEMBL2298799 0.78 KDM4E (0.33) ALDH1A1KDM4EUSP2TSHRCSF1R
SCHEMBL10724382 0.77 PKM (0.34) ALDH1A1TP53SMN1; SMN2KMT2AMAPK1
SCHEMBL5209607 0.77 ALDH1A1 (0.54) ALDH1A1KDM4EUSP2TSHRPRKAG1
SCHEMBL5204512 0.77 KDM4E (0.43) ALDH1A1KDM4EUSP2TSHRPRKAG1
SCHEMBL10729447 0.77 HTT (0.34) ALDH1A1KDM4EHPGDSMN1; SMN2KMT2A
SCHEMBL8141330 0.77 CYP1A2 (0.32)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0958292-B1 4-(3-HETEROCYCLYL-1-BENZOYL)PYRAZOLES AND THEIR USE AS HERBICIDES BASF AG (DE) 2007-01-03 EP disclosed
US-6165944-A 4-(3-heterocyclyl-1-benzoyl) pyrazoles and their use as herbicides BASF AKTIENGESELLSCHAFT (DE) 2000-12-26 US disclosed
EP-0958292-A1 4-(3-HETEROCYCLYL-1-BENZOYL)PYRAZOLES AND THEIR USE AS HERBICIDES BASF AKTIENGESELLSCHAFT (DE) 1999-11-24 EP disclosed
WO-1998031682-A1 4-(3-HETEROCYCLYL-1-BENZOYL)PYRAZOLES AND THEIR USE AS HERBICIDES BASF AKTIENGESELLSCHAFT (DE) 1998-07-23 WO disclosed