Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.42 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | SMO | Q99835 | 1/20 | 0.42 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.42 |
| ▸ | RBP4 | P02753 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5203757 | 0.90 | NPC1 (0.57) | ALDH1A1SMN1; SMN2HSD11B1TPSAB1KMT2A | |
| SCHEMBL4862016 | 0.88 | SLC5A1 (0.49) | ALDH1A1SMN1; SMN2GAASIGMAR1HDAC3 | |
| SCHEMBL5204138 | 0.87 | MGLL (0.49) | ALDH1A1SMN1; SMN2GAASIGMAR1MGLL | |
| SCHEMBL5202168 | 0.86 | PROKR1 (0.47) | ALDH1A1SMN1; SMN2TPSAB1KMT2ARAB9A | |
| SCHEMBL5204500 | 0.85 | TPSAB1 (0.47) | ALDH1A1SMN1; SMN2TPSAB1KMT2APROKR1 | |
| SCHEMBL5203686 | 0.85 | SLC5A1 (0.49) | HSD11B1SIGMAR1HDAC3HDAC1HDAC2 | |
| SCHEMBL4862667 | 0.83 | TSHR (0.47) | ALDH1A1SMN1; SMN2HSD11B1TPSAB1KMT2A | |
| SCHEMBL3598394 | 0.83 | SIGMAR1 (0.57) | HSD11B1GAATDP1KMT2AMEN1 | |
| SCHEMBL4853030 | 0.83 | HDAC3 (0.46) | ALDH1A1SMN1; SMN2GAASIGMAR1RBP4 | |
| SCHEMBL5203268 | 0.81 | GAA (0.48) | ALDH1A1SMN1; SMN2HSD11B1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654253-B1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-03 | — | — | EP | claimed |