Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | METAP1 | P53582 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL71518 | 0.73 | NPSR1 (0.59) | L3MBTL1NPSR1KDM4EALDH1A1MAPT | |
| SCHEMBL360646 | 0.72 | L3MBTL1 (0.39) | L3MBTL1ATRNPSR1KDM4EALDH1A1 | |
| SCHEMBL1761087 | 0.71 | L3MBTL1 (0.38) | L3MBTL1ATRNPSR1KDM4EALDH1A1 | |
| SCHEMBL29756271 | 0.69 | L3MBTL1 (0.53) | L3MBTL1ATRNPSR1KDM4EALDH1A1 | |
| SCHEMBL28036275 | 0.69 | L3MBTL1 (0.53) | L3MBTL1ATRNPSR1KDM4EALDH1A1 | |
| SCHEMBL9632764 | 0.68 | NPSR1 (0.52) | L3MBTL1NPSR1KDM4EALDH1A1MAPT | |
| SCHEMBL162243 | 0.66 | L3MBTL1 (0.53) | L3MBTL1NPSR1KDM4EALDH1A1MAPT | |
| SCHEMBL360639 | 0.66 | NPSR1 (0.50) | L3MBTL1NPSR1KDM4EALDH1A1MAPT | |
| SCHEMBL871602 | 0.66 | NPSR1 (0.50) | L3MBTL1NPSR1KDM4EALDH1A1LMNA | |
| SCHEMBL361255 | 0.66 | KDM4E (0.58) | L3MBTL1NPSR1KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858862-A1 | PYRAZINE -2-CARBOXAMIDE DERIVATIVES AS mGluR5 ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2007-11-28 | — | — | EP | disclosed |
| WO-2006094691-A1 | PYRAZINE -2-CARBOXAMIDE DERIVATIVES AS mGluR5 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-09-14 | — | — | WO | disclosed |