Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.39 |
| ▸ | PIN4 | Q9Y237 | 1/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.39 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SI | P14410 | 1/20 | 0.39 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3542930 | 0.86 | ALOX5 (0.46) | PKMEGFRKMT2ATDP1SMN1; SMN2 | |
| SCHEMBL13241550 | 0.79 | PKM (0.40) | PKMEGFRKMT2ATDP1SMN1; SMN2 | |
| SCHEMBL21437647 | 0.77 | PKM (0.42) | PKMEGFRKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL11468321 | 0.76 | PKM (0.38) | PKMEGFRKMT2ATDP1SMN1; SMN2 | |
| SCHEMBL4989578 | 0.76 | EGFR (0.47) | PKMEGFRKMT2ATDP1SMN1; SMN2 | |
| SCHEMBL68340 | 0.75 | PKM (0.60) | PKMKMT2ASMN1; SMN2ALDH1A1CYP4F2 | |
| SCHEMBL31426029 | 0.74 | MTNR1A (0.47) | PKMCYP4F2CYP4A11 | |
| SCHEMBL1608031 | 0.74 | — | — | |
| SCHEMBL13839096 | 0.74 | SMN1; SMN2 (0.44) | PKMKMT2ATDP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1009146 | 0.73 | PKM (0.58) | PKMEGFRSMN1; SMN2ALDH1A1CYP4F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558253-A4 | PIPERIDINYL-ALPHA-AMINOAMIDE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO INC (US) | 2007-07-25 | — | — | EP | disclosed |
| US-20050250814-A1 | Piperidinyl-alpha-aminoamide modulators of chemokine receptor activity | MERCK SHARP & DOHME CORP. | 2005-11-10 | — | — | US | disclosed |
| EP-1558253-A2 | PIPERIDINYL-ALPHA-AMINOAMIDE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Merck & Co., Inc. (US) | 2005-08-03 | — | — | EP | disclosed |
| WO-2004042351-A2 | PIPERIDINYL-ALPHA-AMINOAMIDE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO., INC. (US) | 2004-05-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050250814-A1 | Piperidinyl-alpha-aminoamide modulators of chemokine receptor activity | CCR2, CCR1, CCRL2 | PKM 2980/4885EGFR 707/4885KMT2A 1675/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.