Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | AGPAT2 | O15120 | 4/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | DCK | P27707 | 1/20 | 0.37 |
| ▸ | PGK1 | P00558 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6504950 | 0.78 | KDM4E (0.48) | MAPK1SMN1; SMN2DCKMEN1KMT2A | |
| SCHEMBL5181345 | 0.74 | ADORA1 (0.51) | PTGS2PTGS1ADORA2AADORA1MAPK1 | |
| SCHEMBL5305206 | 0.73 | PTGS2 (0.53) | PTGS2PTGS1ADORA2AADORA1SMN1; SMN2 | |
| SCHEMBL3602925 | 0.72 | HSP90AA1 (0.51) | MAPK1SMN1; SMN2HSP90AA1HSP90AB1MEN1 | |
| SCHEMBL5277858 | 0.69 | HRH4 (0.48) | PTGS2PTGS1ADORA2AADORA1HSP90AA1 | |
| SCHEMBL3450830 | 0.69 | TUBB4A (0.49) | MAPK1AGPAT2GAAMEN1KMT2A | |
| SCHEMBL5191007 | 0.69 | RAB9A (0.48) | ADORA2AADORA1SMN1; SMN2HSP90AA1GAA | |
| SCHEMBL25129319 | 0.68 | PTGS2 (0.63) | PTGS2PTGS1ADORA2AADORA1 | |
| SCHEMBL31074324 | 0.68 | PTGS2 (0.63) | PTGS2PTGS1ADORA2AADORA1 | |
| SCHEMBL28811659 | 0.67 | MCHR1 (0.56) | PTGS2PTGS1ADORA2AADORA1HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1796673-A2 | NOVEL PYRIMIDINE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM | Reddy US Therapeutics, Inc. (US) | 2007-06-20 | — | — | EP | disclosed |
| WO-2006034473-A2 | NOVEL PYRIMIDINE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM | REDDY US THERAPEUTICS, INC. (US) | 2006-03-30 | — | — | WO | disclosed |