Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC1 | P07992 | 1/20 | 0.60 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.51 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.51 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.51 |
| ▸ | TTR | P02766 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.51 |
| ▸ | BCL2 | P10415 | 1/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9972948 | 0.84 | RAB9A (0.61) | HDAC6HDAC1HDAC2HDAC3HDAC8 | |
| SCHEMBL11205535 | 0.84 | ERCC1 (0.69) | ERCC1ERCC4ALDH1A1HPGDHDAC6 | |
| SCHEMBL28893791 | 0.83 | ERCC1 (0.73) | ERCC1ERCC4HPGDHDAC6HDAC1 | |
| SCHEMBL12697047 | 0.80 | SMN1; SMN2 (0.64) | ERCC1ERCC4HPGDHDAC6HDAC1 | |
| SCHEMBL12172996 | 0.79 | HPGD (0.60) | ALDH1A1HPGDLMNA | |
| SCHEMBL457082 | 0.79 | HDAC6 (0.79) | ERCC1ERCC4ALDH1A1HPGDHDAC6 | |
| SCHEMBL9302673 | 0.78 | MAPK14 (0.75) | ALDH1A1HPGDHDAC6HDAC1HDAC2 | |
| SCHEMBL12172992 | 0.78 | SMN1; SMN2 (0.68) | ERCC1ERCC4HPGDLMNARAB9A | |
| SCHEMBL11901042 | 0.78 | HDAC6 (0.70) | ERCC1ERCC4ALDH1A1HPGDHDAC6 | |
| SCHEMBL4977146 | 0.77 | ALDH1A1 (0.65) | ERCC1ERCC4ALDH1A1HPGDHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633715-B1 | 2-(6-AMINO-PYRIDIN-3-YL)-2-HYDROXYETHYLAMINE DERIVATIVES AS BETA 2-ADRENOCEPTORS AGONISTS | PFIZER LTD (GB) | 2007-09-05 | — | — | EP | disclosed |
| EP-1730103-A1 | FORMAMIDE DERIVATIVES USEFUL AS ADRENOCEPTOR | Pfizer Limited (GB) | 2006-12-13 | — | — | EP | disclosed |
| WO-2005092840-A1 | FORMAMIDE DERIVATIVES USEFUL AS ADRENOCEPTOR | PFIZER LIMITED (GB) | 2005-10-06 | — | — | WO | disclosed |