Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | DRD3 | P35462 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMO | Q99835 | 2/20 | 0.33 |
| ▸ | CCNK | O75909 | 1/20 | 0.33 |
| ▸ | CCND3 | P30281 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5214101 | 0.94 | ROCK2 (0.35) | FPR2DRD2DRD3KCNH2MEN1 | |
| SCHEMBL5808116 | 0.87 | FPR2 (0.38) | FPR2DRD2DRD3KCNH2MEN1 | |
| SCHEMBL5165708 | 0.87 | FPR2 (0.40) | FPR2KCNH2TRPV1HSD11B1 | |
| SCHEMBL5214300 | 0.83 | HRH3 (0.37) | FPR2DRD2DRD3KCNH2MEN1 | |
| SCHEMBL5210548 | 0.82 | DGAT1 (0.36) | FPR2DRD2DRD3KCNH2MEN1 | |
| SCHEMBL5213590 | 0.81 | EGLN1 (0.34) | FPR2DRD2DRD3HTR2AHRH3 | |
| SCHEMBL5166623 | 0.80 | ROCK2 (0.40) | KCNH2TRPV1HSD11B1 | |
| SCHEMBL5163829 | 0.79 | FPR2 (0.41) | FPR2 | |
| SCHEMBL5210531 | 0.77 | HRH3 (0.35) | DRD2DRD3KCNH2HTR2AHRH3 | |
| SCHEMBL5166513 | 0.75 | ELANE (0.41) | DRD2KMT2AHTR2AHRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753745-A2 | PYRAZINYLMETHYL LACTAM DERIVATIVES | Pfizer Products Inc. (US) | 2007-02-21 | — | — | EP | claimed |
| US-20050282816-A1 | Pyrazinylmethyl lactam derivatives | PFIZER INC | 2005-12-22 | — | — | US | claimed |
| WO-2005113535-A2 | PYRAZINYLMETHYL LACTAM DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2005-12-01 | — | — | WO | claimed |
| EP-1753745-A2 | PYRAZINYLMETHYL LACTAM DERIVATIVES | Pfizer Products Inc. (US) | 2007-02-21 | — | — | EP | disclosed |
| US-20050282816-A1 | Pyrazinylmethyl lactam derivatives | PFIZER INC | 2005-12-22 | — | — | US | disclosed |
| WO-2005113535-A2 | PYRAZINYLMETHYL LACTAM DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2005-12-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050282816-A1 | Pyrazinylmethyl lactam derivatives | HTR1A, HTR1D, HTR1B | FPR2 379/4885DRD2 62/4885DRD3 57/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.