Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 3/20 | 0.33 |
| ▸ | DRD3 | P35462 | 3/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | F9 | P00740 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CCNK | O75909 | 1/20 | 0.33 |
| ▸ | CCND3 | P30281 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.32 |
| ▸ | FPR2 | P25090 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | SMO | Q99835 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5811923 | 0.87 | DGAT1 (0.35) | DGAT1DRD2DRD3KCNH2MEN1 | |
| SCHEMBL5214101 | 0.83 | ROCK2 (0.35) | DRD2DRD3HTR2AKCNH2MEN1 | |
| SCHEMBL5214801 | 0.82 | FPR2 (0.39) | DRD2DRD3HTR2AKCNH2MEN1 | |
| SCHEMBL5592486 | 0.78 | DRD2 (0.39) | DGAT1DRD2DRD3HTR2AKCNH2 | |
| SCHEMBL5592512 | 0.78 | DRD2 (0.39) | DGAT1DRD2DRD3HTR2AKCNH2 | |
| SCHEMBL5611716 | 0.78 | DRD2 (0.39) | DGAT1DRD2DRD3HTR2AKCNH2 | |
| Hydrochloric Acid SCHEMBL5739570 | 0.78 | DRD2 (0.38) | DGAT1DRD2DRD3HTR2AKCNH2 | |
| SCHEMBL5739125 | 0.76 | F9 (0.36) | DGAT1DRD2DRD3KCNH2F9 | |
| SCHEMBL5739972 | 0.76 | F9 (0.37) | DGAT1DRD2DRD3HTR2AKCNH2 | |
| SCHEMBL5737237 | 0.76 | HSD11B1 (0.39) | DGAT1DRD2DRD3HTR2AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753745-A2 | PYRAZINYLMETHYL LACTAM DERIVATIVES | Pfizer Products Inc. (US) | 2007-02-21 | — | — | EP | claimed |
| US-20050282816-A1 | Pyrazinylmethyl lactam derivatives | PFIZER INC | 2005-12-22 | — | — | US | claimed |
| WO-2005113535-A2 | PYRAZINYLMETHYL LACTAM DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2005-12-01 | — | — | WO | claimed |
| EP-1753745-A2 | PYRAZINYLMETHYL LACTAM DERIVATIVES | Pfizer Products Inc. (US) | 2007-02-21 | — | — | EP | disclosed |
| US-20050282816-A1 | Pyrazinylmethyl lactam derivatives | PFIZER INC | 2005-12-22 | — | — | US | disclosed |
| WO-2005113535-A2 | PYRAZINYLMETHYL LACTAM DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2005-12-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050282816-A1 | Pyrazinylmethyl lactam derivatives | HTR1A, HTR1D, HTR1B | DGAT1 4667/4885DRD2 62/4885DRD3 57/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.