Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.59 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.59 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | AHR | P35869 | 1/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.59 |
| ▸ | NQO2 | P16083 | 1/20 | 0.57 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.56 |
| ▸ | KIF11 | P52732 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | FBP1 | P09467 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22468790 | 1.00 | MAOB (0.59) | MAOBCYP1A1CYP1B1ALDH1A1TSHR | |
| SCHEMBL521925 | 1.00 | MAOB (0.59) | MAOBCYP1A1CYP1B1ALDH1A1TSHR | |
| SCHEMBL22931544 | 0.90 | AHR (0.68) | CYP1A1CYP1B1AHRPTGS1NQO2 | |
| SCHEMBL13790273 | 0.90 | AHR (0.68) | CYP1A1CYP1B1AHRPTGS1NQO2 | |
| SCHEMBL13790263 | 0.90 | AHR (0.68) | CYP1A1CYP1B1AHRPTGS1NQO2 | |
| SCHEMBL6418950 | 0.89 | MAOB (0.58) | MAOBCYP1A1CYP1B1ALDH1A1TSHR | |
| SCHEMBL29507308 | 0.87 | AHR (0.65) | CYP1A1CYP1B1AHRPTGS1NQO2 | |
| SCHEMBL1981457 | 0.86 | ALDH1A1 (0.59) | MAOBCYP1A1CYP1B1ALDH1A1TSHR | |
| SCHEMBL13267807 | 0.83 | CA1 (0.68) | AHRPTGS1NQO2KIF11CYP1A2 | |
| SCHEMBL11971113 | 0.82 | CYP1A2 (0.86) | MAOBCYP1A1CYP1B1ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108570000-A | A kind of drug for treating depression | 郝惠敏 | 2018-09-25 | — | — | CN | disclosed |
| CN-108558754-A | A kind of drug for treating depression | 郝惠敏 | 2018-09-21 | — | — | CN | disclosed |
| CN-108558798-A | A kind of drug for treating depression | 郝惠敏 | 2018-09-21 | — | — | CN | disclosed |
| US-9925153-B2 | Therapeutic agents for skin diseases and conditions | STC.UNM (US) | 2018-03-27 | — | — | US | disclosed |
| US-20160287531-A1 | THERAPEUTIC AGENTS FOR SKIN DISEASES AND CONDITIONS | STC.UNM | 2016-10-06 | — | — | US | disclosed |
| EP-2417082-B1 | CATALYTIC WITTIG AND MITSUNOBU REACTIONS | UNIV TEXAS (US) | 2016-03-16 | — | — | EP | disclosed |
| WO-2015085143-A2 | THERAPEUTIC AGENTS FOR SKIN DISEASES AND CONDITIONS | STC.UNM (US) | 2015-06-11 | — | — | WO | disclosed |
| US-8980954-B2 | Substituted cis- and trans-stilbenes as therapeutic agents | STC.UNM (US) | 2015-03-17 | — | — | US | disclosed |
| US-8901365-B2 | Catalytic Wittig and Mitsunobu reactions | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2014-12-02 | — | — | US | disclosed |
| US-20130178536-A1 | SUBSTITUTED CIS- AND TRANS-STILBENES AS THERAPEUTIC AGENTS | STC.UNM (US) | 2013-07-11 | — | — | US | disclosed |
| US-20120029211-A1 | Catalytic Wittig and Mitsunobu Reactions | THE UNIVERSITY OF TEXAS AT ARLINGTON | 2012-02-02 | — | — | US | disclosed |
| US-20070249647-A1 | Substituted CIS- and trans-stilbenes as therapeutic agents | REGENTS OF THE UNIVERSITY OF NEW MEXICO | 2007-10-25 | — | — | US | disclosed |
| CN-1865206-A | 2,5-diphenyl-1,4-distyyl benzene derivative and its uses in electroluminescent device | UNIV JILIN (CN) | 2006-11-22 | — | — | CN | disclosed |
| US-6392111-B1 | REACTING AROMATIC COMPOUND WITH OLEFIN | STUDIENGESELLSCHAFT KOHLE MBH (DE) | 2002-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160287531-A1 | THERAPEUTIC AGENTS FOR SKIN DISEASES AND CONDITIONS | CUTA, TSLP, ELANE | MAOB 961/4885CYP1A1 1445/4885CYP1B1 1256/4885 |
| US-20070249647-A1 | Substituted CIS- and trans-stilbenes as therapeutic agents | TGFB1, VHL, TMSB10 | MAOB 1359/4885CYP1A1 874/4885CYP1B1 713/4885 |
| US-20130178536-A1 | SUBSTITUTED CIS- AND TRANS-STILBENES AS THERAPEUTIC AGENTS | PSEN1, TERT, PSEN2 | MAOB 933/4885CYP1A1 809/4885CYP1B1 936/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.