Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 7/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5219920 | 0.81 | CYP1A2 (0.43) | CYP1A2ALDH1A1KDM4ESCN9ANPSR1 | |
| SCHEMBL5221921 | 0.78 | XDH (0.41) | ALDH1A1KDM4EGABRA1GABRG2GABRB3 | |
| SCHEMBL22939960 | 0.73 | CYP1A2 (0.59) | CYP1A2SMN1; SMN2ALDH1A1KDM4ESCN9A | |
| SCHEMBL26750381 | 0.71 | ALDH1A1 (0.58) | CYP1A2SMN1; SMN2ALDH1A1TSHRMAPT | |
| SCHEMBL18095773 | 0.69 | CYP1A2 (0.43) | CYP1A2SMN1; SMN2ALDH1A1KDM4EGABRA1 | |
| SCHEMBL6618622 | 0.68 | ALDH1A1 (0.57) | CYP1A2SMN1; SMN2ALDH1A1TSHRMAPT | |
| SCHEMBL24328865 | 0.67 | ALDH1A1 (0.44) | CYP1A2SMN1; SMN2ALDH1A1TSHRMAPT | |
| SCHEMBL8207167 | 0.67 | SMN1; SMN2 (0.59) | SMN1; SMN2ALDH1A1POLBTSHRMAPT | |
| SCHEMBL5217488 | 0.67 | HPGD (0.45) | CYP1A2ALDH1A1KDM4EMAPTCYP2C9 | |
| SCHEMBL10602219 | 0.66 | ALDH1A1 (0.59) | SMN1; SMN2ALDH1A1KDM4ETSHRNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1368318-B1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2007-12-05 | — | — | EP | disclosed |
| US-6864267-B2 | Calcilytic compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2005-03-08 | — | — | US | disclosed |
| EP-1368318-A2 | CALCILYTIC COMPOUNDS | SmithKline Beecham Corporation (US) | 2003-12-10 | — | — | EP | disclosed |
| US-20030212110-A1 | Glandular disorders; bone disorders | SMITHKLINE BEECHAM CORPORATION | 2003-11-13 | — | — | US | disclosed |
| WO-2002007673-A2 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-01-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030212110-A1 | Glandular disorders; bone disorders | CYP24A1, PTH1R, SOST | CYP1A2 4201/4885SMN1; SMN2 4465/4885ALDH1A1 3551/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.