Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.54 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2091652 | 0.83 | ALDH1A1 (0.53) | MEN1HPGDKMT2AALDH1A1MAPT | |
| SCHEMBL2091031 | 0.80 | TDP1 (0.56) | DYRK1AAKR1B1MEN1HPGDKMT2A | |
| SCHEMBL24287678 | 0.78 | PDPK1 (0.58) | PDPK1DYRK1AAKR1B1MEN1HPGD | |
| SCHEMBL77032 | 0.76 | KMT2A (0.68) | MEN1HPGDKMT2AALDH1A1MAPT | |
| SCHEMBL1039915 | 0.76 | PDPK1 (0.59) | PDPK1DYRK1AAKR1B1HPGDKMT2A | |
| SCHEMBL12748196 | 0.73 | PDPK1 (0.51) | PDPK1DYRK1AAKR1B1MEN1HPGD | |
| SCHEMBL6717566 | 0.72 | NPC1 (0.64) | MEN1HPGDKMT2AALDH1A1MAPT | |
| SCHEMBL74065 | 0.71 | PDPK1 (1.00) | PDPK1DYRK1AALDH1A1APPRET | |
| SCHEMBL6544062 | 0.70 | PDPK1 (0.66) | PDPK1DYRK1AAKR1B1MEN1HPGD | |
| SCHEMBL8361492 | 0.70 | PDPK1 (0.47) | PDPK1DYRK1AAKR1B1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1745034-A1 | VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS | AMGEN INC. (US) | 2007-01-24 | — | — | EP | disclosed |
| WO-2005077938-A1 | VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS | AMGEN INC. (US) | 2005-08-25 | — | — | WO | disclosed |