Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.51 |
| ▸ | RIPK2 | O43353 | 6/20 | 0.45 |
| ▸ | LCK | P06239 | 6/20 | 0.45 |
| ▸ | KDR | P35968 | 6/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 6/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | FASN | P49327 | 1/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.40 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5801938 | 0.88 | TGFBR1 (0.50) | ARRIPK2LCKKDRTGFBR1 | |
| SCHEMBL4155826 | 0.79 | NPC1 (0.53) | RIPK2LCKKDRTGFBR1FASN | |
| SCHEMBL5232863 | 0.79 | AR (0.46) | ARRIPK2LCKKDRTGFBR1 | |
| Hydrochloric Acid SCHEMBL6384354 | 0.77 | NPC1 (0.51) | RIPK2LCKKDRTGFBR1FASN | |
| SCHEMBL5222484 | 0.76 | RIPK2 (0.45) | RIPK2LCKKDRTGFBR1CSNK1D | |
| SCHEMBL5222099 | 0.76 | AURKA (0.55) | RIPK2LCKKDRTGFBR1FASN | |
| SCHEMBL5802265 | 0.73 | JAK2 (0.49) | RIPK2LCKKDRTGFBR1KDM1A | |
| SCHEMBL5785066 | 0.73 | ALOX5AP (0.39) | RIPK2LCKKDRTGFBR1KDM1A | |
| SCHEMBL1851823 | 0.72 | KIF11 (0.49) | ALOX5APFEN1 | |
| SCHEMBL29598464 | 0.72 | HDAC6 (0.46) | RIPK2LCKKDRTGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799661-A1 | NEW HYDROXYMETHYLBENZOTHIAZOLES AMIDES | AstraZeneca AB (SE) | 2007-06-27 | — | — | EP | claimed |
| WO-2006038871-A1 | NEW HYDROXYMETHYLBENZOTHIAZOLES AMIDES | ASTRAZENECA AB (SE) | 2006-04-13 | — | — | WO | claimed |