SCHEMBL5801938

SCHEMBL5801938

CC(C)(C)c1ccc(C(N)=O)cc1-c1ccc2scnc2c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TGFBR1 P36897 7/20 0.50
RIPK2 O43353 7/20 0.50
LCK P06239 7/20 0.50
KDR P35968 7/20 0.50
CSNK1D P48730 1/20 0.44
CSNK1E P49674 1/20 0.44
AR P10275 3/20 0.41
ALOX5AP P20292 1/20 0.41
FEN1 P39748 1/20 0.41
FASN P49327 1/20 0.40
KDM1A O60341 1/20 0.39
FFAR1 O14842 1/20 0.39
KDM4E B2RXH2 1/20 0.38
NPC1 O15118 1/20 0.38
RAB9A P51151 1/20 0.38
HKDC1 Q2TB90 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
PRMT5 O14744 1/20 0.37
JAK2 O60674 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5222476 0.88 AR (0.51) TGFBR1RIPK2LCKKDRCSNK1D
SCHEMBL5232863 0.81 AR (0.46) TGFBR1RIPK2LCKKDRAR
SCHEMBL4155826 0.79 NPC1 (0.53) TGFBR1RIPK2LCKKDRFASN
Hydrochloric Acid SCHEMBL6384354 0.77 NPC1 (0.51) TGFBR1RIPK2LCKKDRFASN
SCHEMBL5801942 0.76 RIPK2 (0.50) TGFBR1RIPK2LCKKDRCSNK1D
SCHEMBL5222099 0.76 AURKA (0.55) TGFBR1RIPK2LCKKDRCSNK1D
SCHEMBL5802265 0.73 JAK2 (0.49) TGFBR1RIPK2LCKKDRCSNK1D
SCHEMBL5225861 0.72 BCAT2 (0.49) TGFBR1RIPK2LCKKDRALOX5AP
SCHEMBL22926283 0.71 FASN (0.54) TGFBR1RIPK2LCKKDRFASN
SCHEMBL162869 0.70 NPC1 (0.72) KDM4ENPC1RAB9AHKDC1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1622884-A1 NEW HETEROCYCLIC AMIDES EXHIBITING AN INHIBITORY ACTIVITY AT THE VANILLOID RECEPTOR 1 (VR1). AstraZeneca AB (SE) 2006-02-08 EP claimed
WO-2004096784-A1 NEW HETEROCYCLIC AMIDES EXHIBITING AN INHIBITORY ACTIVITY AT THE VANILLOID RECEPTOR 1 (VR1). ASTRAZENECA AB (SE) 2004-11-11 WO claimed
EP-1622884-A1 NEW HETEROCYCLIC AMIDES EXHIBITING AN INHIBITORY ACTIVITY AT THE VANILLOID RECEPTOR 1 (VR1). AstraZeneca AB (SE) 2006-02-08 EP disclosed
WO-2004096784-A1 NEW HETEROCYCLIC AMIDES EXHIBITING AN INHIBITORY ACTIVITY AT THE VANILLOID RECEPTOR 1 (VR1). ASTRAZENECA AB (SE) 2004-11-11 WO disclosed