Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.49 |
| ▸ | RIPK2 | O43353 | 6/20 | 0.44 |
| ▸ | LCK | P06239 | 6/20 | 0.44 |
| ▸ | KDR | P35968 | 6/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 6/20 | 0.44 |
| ▸ | FASN | P49327 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.42 |
| ▸ | STK4 | Q13043 | 1/20 | 0.42 |
| ▸ | STK3 | Q13188 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5802267 | 0.79 | JAK2 (0.49) | JAK2RIPK2LCKKDRTGFBR1 | |
| SCHEMBL4155826 | 0.74 | NPC1 (0.53) | RIPK2LCKKDRTGFBR1FASN | |
| SCHEMBL5801938 | 0.73 | TGFBR1 (0.50) | JAK2RIPK2LCKKDRTGFBR1 | |
| SCHEMBL5222476 | 0.73 | AR (0.51) | JAK2RIPK2LCKKDRTGFBR1 | |
| SCHEMBL5232863 | 0.73 | AR (0.46) | RIPK2LCKKDRTGFBR1FASN | |
| Hydrochloric Acid SCHEMBL6384354 | 0.72 | NPC1 (0.51) | RIPK2LCKKDRTGFBR1FASN | |
| SCHEMBL31428619 | 0.71 | CRBN (0.60) | JAK2FASNALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL5222099 | 0.71 | AURKA (0.55) | RIPK2LCKKDRTGFBR1FASN | |
| Formamide SCHEMBL19667116 | 0.70 | MAPK14 (0.41) | LCKKDRLRRK2STK4STK3 | |
| SCHEMBL3120753 | 0.69 | ALDH1A1 (0.54) | KDM4EALDH1A1LMNAPOLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1622884-A1 | NEW HETEROCYCLIC AMIDES EXHIBITING AN INHIBITORY ACTIVITY AT THE VANILLOID RECEPTOR 1 (VR1). | AstraZeneca AB (SE) | 2006-02-08 | — | — | EP | disclosed |
| WO-2004096784-A1 | NEW HETEROCYCLIC AMIDES EXHIBITING AN INHIBITORY ACTIVITY AT THE VANILLOID RECEPTOR 1 (VR1). | ASTRAZENECA AB (SE) | 2004-11-11 | — | — | WO | disclosed |