Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | CA12 | O43570 | 1/20 | 0.59 |
| ▸ | CA1 | P00915 | 1/20 | 0.59 |
| ▸ | CA2 | P00918 | 1/20 | 0.59 |
| ▸ | CA9 | Q16790 | 1/20 | 0.59 |
| ▸ | KIF11 | P52732 | 4/20 | 0.57 |
| ▸ | PGR | P06401 | 1/20 | 0.53 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12054668 | 0.89 | KEAP1 (0.75) | KEAP1ALDH1A1SMN1; SMN2LMNAHPGD | |
| SCHEMBL31041151 | 0.82 | KIF11 (0.79) | KEAP1ALDH1A1SMN1; SMN2LMNAHPGD | |
| SCHEMBL82733 | 0.80 | CA1 (0.64) | KEAP1ALDH1A1SMN1; SMN2LMNAHPGD | |
| Lithium SCHEMBL31041154 | 0.80 | KIF11 (0.76) | KEAP1ALDH1A1SMN1; SMN2LMNAHPGD | |
| SCHEMBL1488032 | 0.80 | ALDH1A1 (0.68) | KEAP1ALDH1A1SMN1; SMN2LMNAHPGD | |
| SCHEMBL11562750 | 0.78 | CA1 (0.61) | KEAP1ALDH1A1SMN1; SMN2LMNAHPGD | |
| SCHEMBL7057622 | 0.78 | KEAP1 (0.60) | KEAP1ALDH1A1SMN1; SMN2LMNAHPGD | |
| SCHEMBL96017 | 0.78 | KEAP1 (0.60) | KEAP1ALDH1A1SMN1; SMN2LMNAHPGD | |
| SCHEMBL3315266 | 0.78 | KEAP1 (0.60) | KEAP1ALDH1A1SMN1; SMN2LMNAHPGD | |
| SCHEMBL518114 | 0.78 | CA1 (0.61) | KEAP1ALDH1A1SMN1; SMN2LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 423 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10646482-B2 | Nitrogen-containing heteroaryl compounds and methods of use thereof | FIBROGEN, INC. (US) | 2020-05-12 | — | — | US | claimed |
| US-20190240213-A1 | NOVEL NITROGEN-CONTAINING HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF | FIBROGEN, INC. | 2019-08-08 | — | — | US | claimed |
| US-10092558-B2 | Nitrogen-containing heteroaryl compounds and methods of use thereof | FIBROGEN, INC. (US) | 2018-10-09 | — | — | US | claimed |
| US-20170035747-A1 | NOVEL NITROGEN-CONTAINING HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF | FIBROGEN, INC. | 2017-02-09 | — | — | US | claimed |
| US-20160317523-A1 | Treatment of Retinopathy of Prematurity (ROP) | THE CLEVELAND CLINIC FOUNDATION | 2016-11-03 | — | — | US | claimed |
| WO-2015095757-A1 | TREATMENT OF RETINOPATHY OF PREMATURITY (ROP) | THE CLEVELAND CLINIC FOUNDATION (US) | 2015-06-25 | — | — | WO | claimed |
| US-8916585-B2 | Nitrogen-containing heteroaryl compounds and methods of use thereof | FIBROGEN, INC. (US) | 2014-12-23 | — | — | US | claimed |
| US-20130178417-A1 | NOVEL NITROGEN-CONTAINING HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF | FIBROGEN, INC. | 2013-07-11 | — | — | US | claimed |
| US-8017625-B2 | Nitrogen-containing heteroaryl compounds and methods of use thereof | FIBROGEN, INC. (US) | 2011-09-13 | — | — | US | claimed |
| EP-2357175-A1 | isoquinoline derivatives AND THEIR USE IN INCREASING ENDOGENEOUS ERYTHROPOIETIN | Fibrogen, Inc. (US) | 2011-08-17 | — | — | EP | claimed |
| EP-0930528-B1 | Silver halide photographic light-sensitive material | FUJI PHOTO FILM CO LTD (JP) | 2003-10-22 | — | — | EP | claimed |
| US-6340372-B1 | Compositions for dyeing keratin fibers containing S-oxide-thiazolo-azoles and/or S,S-dioxide-thiazolo-azoles; their use for dyeing as couplers, method of dyeing | L'OREAL S.A. (FR) | 2002-01-22 | — | — | US | claimed |
| US-6251576-B1 | AN AROMATIC SULFONAMIDE COMPOUND CONTAINING A HYDROXYL GROUP | FUJI PHOTO FILM CO., LTD. (JP) | 2001-06-26 | — | — | US | claimed |
| US-6139589-A | HAIR DYES | L'OREAL S.A. (FR) | 2000-10-31 | — | — | US | claimed |
| US-6063136-A | Compositions containing pyrrolo-oxazole couplers for dyeing keratin fibers and dyeing methods | L'OREAL S.A. (FR) | 2000-05-16 | — | — | US | claimed |
| EP-0930528-A1 | Silver halide photographic light-sensitive material | FUJI PHOTO FILM CO., LTD. (JP) | 1999-07-21 | — | — | EP | claimed |
| US-5116990-A | MAGENTA DYE-FORMING COUPLER | FUJI PHOTO FILM CO., LTD. (JP) | 1992-05-26 | — | — | US | claimed |
| EP-0170164-B1 | SILVER HALIDE COLOR PHOTOGRAPHIC LIGHT-SENSITIVE MATERIAL | FUJI PHOTO FILM CO., LTD. (JP) | 1988-10-05 | — | — | EP | claimed |
| US-H122-H | PYRAZOLOAZOLE-TYPE MAGENTA COUPLER DISPERSED IN A HIGH-BOILING PHOSPHATE SOLVENT | FUJI PHOTO FILM CO., LTD. (JP) | 1986-09-02 | — | — | US | claimed |
| EP-0170164-A2 | Silver halide color photographic light-sensitive material | FUJI PHOTO FILM CO., LTD. (JP) | 1986-02-05 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130178417-A1 | NOVEL NITROGEN-CONTAINING HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF | HIF1AN, EGLN3, EGLN2 | KEAP1 784/4885ALDH1A1 1908/4885SMN1; SMN2 2604/4885 |
| US-20170035747-A1 | NOVEL NITROGEN-CONTAINING HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF | HIF1AN, EGLN3, EGLN2 | KEAP1 784/4885ALDH1A1 1908/4885SMN1; SMN2 2604/4885 |
| US-10646482-B2 | Nitrogen-containing heteroaryl compounds and methods of use thereof | HIF1AN, HIF1A, EGLN2 | KEAP1 550/4885ALDH1A1 1476/4885SMN1; SMN2 2209/4885 |
| US-20190240213-A1 | NOVEL NITROGEN-CONTAINING HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF | HIF1AN, EGLN3, EGLN2 | KEAP1 784/4885ALDH1A1 1908/4885SMN1; SMN2 2604/4885 |
| US-10092558-B2 | Nitrogen-containing heteroaryl compounds and methods of use thereof | HIF1AN, HIF1A, EGLN2 | KEAP1 550/4885ALDH1A1 1476/4885SMN1; SMN2 2209/4885 |
| US-20160317523-A1 | Treatment of Retinopathy of Prematurity (ROP) | VEGFA, ALDH1A2, PGF | KEAP1 2048/4885ALDH1A1 149/4885SMN1; SMN2 119/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.