Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.38 |
| ▸ | BACE1 | P56817 | 3/20 | 0.38 |
| ▸ | CTSD | P07339 | 1/20 | 0.38 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | CTSC | P53634 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5223660 | 1.00 | RAB9A (0.38) | RAB9ABACE1CTSDBACE2CYP2C19 | |
| SCHEMBL5226207 | 0.82 | CTSD (0.38) | BACE1CTSDBACE2CTSSCTSK | |
| SCHEMBL5226201 | 0.82 | CTSD (0.38) | BACE1CTSDBACE2CTSSCTSK | |
| SCHEMBL5223208 | 0.82 | CTSD (0.38) | RAB9ABACE1CTSDBACE2NPC1 | |
| SCHEMBL5223196 | 0.82 | CTSD (0.38) | RAB9ABACE1CTSDBACE2NPC1 | |
| SCHEMBL5224498 | 0.82 | CTSD (0.34) | BACE1CTSDBACE2 | |
| SCHEMBL5224505 | 0.82 | CTSD (0.34) | BACE1CTSDBACE2 | |
| Hydrochloric Acid SCHEMBL5226221 | 0.76 | RAB9A (0.42) | RAB9ABACE1CTSDBACE2CYP2C19 | |
| SCHEMBL5221569 | 0.73 | NPC1 (0.42) | RAB9ACYP2C19NPC1LMNA | |
| SCHEMBL5221576 | 0.73 | NPC1 (0.42) | RAB9ACYP2C19NPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |