Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5227512 | 0.77 | KMT2A (0.48) | SMN1; SMN2TP53KMT2AMEN1PTGS2 | |
| SCHEMBL5223978 | 0.74 | GAA (0.50) | ALDH1A1SMN1; SMN2ALOX12ALOX15KMT2A | |
| SCHEMBL5225056 | 0.73 | MAPK11 (0.57) | ALDH1A1SMN1; SMN2KMT2AMEN1PTGS2 | |
| SCHEMBL5222119 | 0.72 | KMT2A (0.44) | ALDH1A1SMN1; SMN2TP53KMT2AMEN1 | |
| SCHEMBL5225376 | 0.71 | ALOX5 (0.51) | ALDH1A1SMN1; SMN2TP53KMT2AMEN1 | |
| SCHEMBL5677687 | 0.71 | TP53 (0.53) | ALDH1A1SMN1; SMN2ALOX12TP53CYP3A4 | |
| SCHEMBL5226722 | 0.71 | KMT2A (0.43) | ALDH1A1SMN1; SMN2TP53KMT2AMEN1 | |
| SCHEMBL5227509 | 0.70 | MAPT (0.55) | ALDH1A1SMN1; SMN2TP53TSHRKMT2A | |
| SCHEMBL5224164 | 0.70 | ADORA1 (0.49) | ALDH1A1SMN1; SMN2TSHRKMT2AMEN1 | |
| SCHEMBL5227004 | 0.70 | NPC1 (0.62) | ALDH1A1SMN1; SMN2KMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1300399-B1 | PHENYLPYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME | KOWA CO (JP) | 2007-08-22 | — | — | EP | disclosed |
| US-6664256-B1 | Interleukin- 1 beta inhibitors | KOWA CO., LTD. (JP) | 2003-12-16 | — | — | US | disclosed |
| EP-1300399-A1 | PHENYLPYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME | Kowa Co., Ltd. (JP) | 2003-04-09 | — | — | EP | disclosed |