Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.46 |
| ▸ | RXRA | P19793 | 1/20 | 0.46 |
| ▸ | RXRB | P28702 | 1/20 | 0.46 |
| ▸ | RXRG | P48443 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | CASP1 | P29466 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5225376 | 0.86 | ALOX5 (0.51) | GAALMNAALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL5227512 | 0.82 | KMT2A (0.48) | MAPTLMNAKDM4EPKMSMN1; SMN2 | |
| SCHEMBL5365533 | 0.80 | GAA (0.51) | GAAMAPTLMNAATMALDH1A1 | |
| SCHEMBL5223497 | 0.77 | SMN1; SMN2 (0.54) | GAAMAPTATMALDH1A1KDM4E | |
| SCHEMBL5223691 | 0.74 | ALDH1A1 (0.46) | GAAMAPTLMNAALDH1A1KDM4E | |
| SCHEMBL4130869 | 0.73 | POLB (0.50) | MAPTLMNAATMALDH1A1KDM4E | |
| SCHEMBL6325808 | 0.72 | MAPT (0.62) | MAPTLMNAATMALDH1A1KDM4E | |
| SCHEMBL3945526 | 0.71 | GAA (0.53) | GAAALDH1A1KDM4EHPGDALOX15 | |
| SCHEMBL1566761 | 0.70 | FFAR1 (0.73) | MAPTLMNAALDH1A1KDM4EPKM | |
| SCHEMBL20885640 | 0.70 | FFAR1 (0.51) | GAALMNAFFAR1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1300399-B1 | PHENYLPYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME | KOWA CO (JP) | 2007-08-22 | — | — | EP | disclosed |
| US-6664256-B1 | Interleukin- 1 beta inhibitors | KOWA CO., LTD. (JP) | 2003-12-16 | — | — | US | disclosed |
| EP-1300399-A1 | PHENYLPYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME | Kowa Co., Ltd. (JP) | 2003-04-09 | — | — | EP | disclosed |