Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.44 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5223978 | 0.82 | GAA (0.50) | KMT2AMEN1PTGS2LMNAMAPT | |
| SCHEMBL5225376 | 0.79 | ALOX5 (0.51) | KMT2AMEN1PTGS2LMNAHTT | |
| SCHEMBL5223691 | 0.77 | ALDH1A1 (0.46) | KMT2AMEN1PTGS2LMNAHTT | |
| SCHEMBL5225056 | 0.73 | MAPK11 (0.57) | KMT2AMEN1PTGS2LMNAMAPT | |
| SCHEMBL5222119 | 0.72 | KMT2A (0.44) | KMT2AMEN1PTGS2LMNAMAPT | |
| SCHEMBL25060794 | 0.72 | MALT1 (0.45) | KMT2AMEN1PTGS2CYP11B1CYP11B2 | |
| SCHEMBL5223497 | 0.72 | SMN1; SMN2 (0.54) | MAPTKDM4ESMN1; SMN2L3MBTL1BACE1 | |
| SCHEMBL5226722 | 0.71 | KMT2A (0.43) | KMT2AMEN1PTGS2LMNAMAPT | |
| SCHEMBL5227004 | 0.70 | NPC1 (0.62) | KMT2AMEN1LMNAMAPTKDM4E | |
| SCHEMBL5227509 | 0.70 | MAPT (0.55) | KMT2AMEN1PTGS2LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1300399-B1 | PHENYLPYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME | KOWA CO (JP) | 2007-08-22 | — | — | EP | disclosed |
| US-6664256-B1 | Interleukin- 1 beta inhibitors | KOWA CO., LTD. (JP) | 2003-12-16 | — | — | US | disclosed |
| EP-1300399-A1 | PHENYLPYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME | Kowa Co., Ltd. (JP) | 2003-04-09 | — | — | EP | disclosed |