Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.51 |
| ▸ | CA2 | P00918 | 2/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | ERN1 | O75460 | 2/20 | 0.40 |
| ▸ | TLR2 | O60603 | 1/20 | 0.40 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.40 |
| ▸ | TLR6 | Q9Y2C9 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.38 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.38 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | CTSG | P08311 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28321749 | 0.94 | PPARA (0.49) | CA1CA2ALOX5PTGS2PPARA | |
| SCHEMBL27775346 | 0.86 | GAA (0.41) | CA1CA2ALOX5PTGS2NPC1 | |
| SCHEMBL19383789 | 0.85 | CA1 (0.40) | CA1CA2ALOX5PTGS2PPARA | |
| SCHEMBL7102162 | 0.84 | CA1 (0.59) | CA1CA2SRCERN1TLR2 | |
| SCHEMBL27854915 | 0.84 | ALOX5 (0.43) | CA1CA2ALOX5PTGS2PPARA | |
| SCHEMBL7187326 | 0.83 | CA1 (0.37) | CA1CA2ALOX5PTGS2PPARA | |
| SCHEMBL16829571 | 0.82 | ALOX5 (0.53) | CA1CA2ALOX5PTGS2PPARA | |
| SCHEMBL8119443 | 0.82 | LMNA (0.45) | CA1CA2PPARAPTGER4PTGER3 | |
| SCHEMBL18394129 | 0.81 | LIPG (0.45) | CA1CA2ALOX5PTGS2PPARA | |
| SCHEMBL2288674 | 0.80 | PTGER4 (0.42) | CA1CA2ALOX5PTGS2PTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3562826-A1 | INTEGRIN ANTAGONISTS | Saint Louis University (US) | 2019-11-06 | — | — | EP | disclosed |
| WO-2018132268-A1 | INTEGRIN ANTAGONISTS | SAINT LOUIS UNIVERSITY (US) | 2018-07-19 | — | — | WO | disclosed |
| EP-1753718-A1 | 3-AMINO-2-PHENYLPYRROLIDINE DERIVATIVES | Pfizer Products Incorporated (US) | 2007-02-21 | — | — | EP | disclosed |
| CN-1914202-A | Process for preparation of 1-(2s,3s)-2-benzhydryl-n-(5-tert-butyl-2-methoxybenzyl)quinuclidin-3-amine | PFIZER PROD INC (US) | 2007-02-14 | — | — | CN | disclosed |
| WO-2005115976-A1 | 3-AMINO-2-PHENYLPYRROLIDINE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2005-12-08 | — | — | WO | disclosed |
| CN-1056373-C | Process for preparing fluoroalkoxybenzylamino derivatives of nitrogen containing heterocycles | PFIZER (US) | 2000-09-13 | — | — | CN | disclosed |
| CN-1067655-A | FLUOROALKOXYBENZYLAMINO DERIVATIVES OF NITROGEN CONTAINING HETEROCYCLES | PFIZER (US) | 1993-01-06 | — | — | CN | disclosed |