Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 3/20 | 0.46 |
| ▸ | ACHE | P22303 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | HPGDS | O60760 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.43 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | HRH2 | P25021 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | SMO | Q99835 | 4/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2761055 | 0.94 | ALDH1A1 (0.46) | HTR7ACHEALDH1A1GLAHSD17B10 | |
| SCHEMBL5226314 | 0.88 | HTR7 (0.46) | HTR7ACHEALDH1A1MAP4K1DRD4 | |
| SCHEMBL1689504 | 0.88 | SMO (0.45) | HTR7ACHEALDH1A1MAP4K1DRD4 | |
| SCHEMBL5737789 | 0.86 | SMO (0.44) | HTR7ALDH1A1MAPTDRD4DRD2 | |
| SCHEMBL7256544 | 0.86 | DRD4 (0.44) | HTR7ACHEALDH1A1MAPTMAP4K1 | |
| SCHEMBL5225912 | 0.86 | MAP4K1 (0.41) | ACHEALDH1A1MAP4K1DRD4DRD2 | |
| SCHEMBL2761085 | 0.86 | DHODH (0.43) | ALDH1A1MAP4K1DRD4DRD2DRD3 | |
| SCHEMBL5224925 | 0.85 | EPHB4 (0.46) | HTR7ACHEDRD4DRD2DRD3 | |
| SCHEMBL5228638 | 0.85 | DRD4 (0.41) | ACHEALDH1A1MAPTMAP4K1DRD4 | |
| SCHEMBL5224366 | 0.85 | SMO (0.44) | HTR7ACHEALDH1A1MAPTMAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1611122-B1 | SUBSTITUTED PYRAZOLE COMPOUNDS | MERCK PATENT GMBH (DE) | 2007-06-13 | — | — | EP | disclosed |