SCHEMBL5226515

SCHEMBL5226515

[CH2]C[C@@H](C(=O)Nc1cnc2ccc(F)cc2c1)c1ccccc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACP1 P24666 2/20 0.51
HDAC3 O15379 7/20 0.46
HDAC1 Q13547 7/20 0.46
HDAC2 Q92769 5/20 0.46
NCOR2 Q9Y618 4/20 0.46
KDR P35968 1/20 0.43
ROCK2 O75116 6/20 0.43
ROCK1 Q13464 1/20 0.43
ADCY6 O43306 1/20 0.42
ADCY3 O60266 1/20 0.42
ADCY9 O60503 1/20 0.42
ADCY5 O95622 1/20 0.42
ADCY8 P40145 1/20 0.42
GCGR P47871 1/20 0.42
ADCY7 P51828 1/20 0.42
ADCY2 Q08462 1/20 0.42
ADCY1 Q08828 1/20 0.42
ADCY4 Q8NFM4 1/20 0.42
HDAC4 P56524 3/20 0.42
HDAC8 Q9BY41 3/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5227514 0.88 ACP1 (0.65) ACP1HDAC3HDAC1HDAC2KDR
SCHEMBL5184807 0.87 ACP1 (0.49) ACP1HDAC3HDAC1HDAC2NCOR2
SCHEMBL5231297 0.79 PABPC1 (0.58) ACP1HDAC3HDAC1HDAC2ROCK2
SCHEMBL22410706 0.76 KDR (0.50) ACP1HDAC3HDAC1HDAC2KDR
SCHEMBL4950201 0.76 ROCK2 (0.46) ACP1HDAC3HDAC1HDAC2KDR
SCHEMBL5185578 0.75 MEN1 (0.48) ACP1KDRROCK2ROCK1ADCY6
SCHEMBL5184940 0.74 ACP1 (0.62) ACP1HDAC3HDAC1HDAC2KDR
SCHEMBL5185024 0.74 ACP1 (0.53) ACP1HDAC3HDAC1HDAC2KDR
SCHEMBL5184424 0.72 ACP1 (0.69) ACP1HDAC3HDAC1HDAC2KDR
SCHEMBL5226513 0.70 RAB9A (0.46) HDAC3HDAC1HDAC2KDRHDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1758920-A1 BACTERIAL EFFLUX PUMP INHIBITORS AND METHODS OF TREATING BACTERIAL INFECTIONS MPEX PHARMACEUTICALS, INC. (US) 2007-03-07 EP disclosed
WO-2005113579-A1 BACTERIAL EFFLUX PUMP INHIBITORS AND METHODS OF TREATING BACTERIAL INFECTIONS MPEX PHARMACEUTICALS, INC. (US) 2005-12-01 WO disclosed