Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 7/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5224724 | 0.89 | KMT2A (0.38) | KMT2AMAPTL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL5229009 | 0.81 | KMT2A (0.34) | KMT2AMAPTL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL5224311 | 0.78 | LMNA (0.45) | KMT2AMAPTL3MBTL1ALDH1A1HSD17B10 | |
| SCHEMBL5232268 | 0.78 | BCL2L11 (0.39) | KMT2AMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL5230462 | 0.78 | HTR1A (0.47) | KMT2AMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL5225671 | 0.78 | KMT2A (0.36) | KMT2AMAPTL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL5226495 | 0.74 | NPSR1 (0.44) | KMT2AMAPTKDM4EALDH1A1TSHR | |
| SCHEMBL1998048 | 0.69 | MAPT (0.36) | KMT2AMAPTL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL2902807 | 0.68 | ALDH1A1 (0.38) | KMT2AMAPTL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL26452828 | 0.67 | KMT2A (0.63) | KMT2AMAPTL3MBTL1MEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1611122-B1 | SUBSTITUTED PYRAZOLE COMPOUNDS | MERCK PATENT GMBH (DE) | 2007-06-13 | — | — | EP | disclosed |