Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 3/20 | 0.40 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | CHIT1 | Q13231 | 4/20 | 0.37 |
| ▸ | CHIA | Q9BZP6 | 4/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.37 |
| ▸ | MPO | P05164 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.35 |
| ▸ | CHI3L1 | P36222 | 1/20 | 0.35 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | PLK1 | P53350 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28957458 | 0.75 | MAOA (0.49) | MAOAMAOBMPOSMYD3CA12 | |
| SCHEMBL4237634 | 0.75 | SLC6A2 (0.50) | CHI3L1 | |
| SCHEMBL3724429 | 0.75 | SLC6A2 (0.50) | CHI3L1 | |
| SCHEMBL5193918 | 0.73 | HTR3A (0.40) | CHIT1CHIAKCNH2CHI3L1 | |
| SCHEMBL4166236 | 0.71 | MAPK1 (0.43) | KCNH2 | |
| SCHEMBL5221700 | 0.68 | SPHK1 (0.66) | SPHK1SPHK2KCNH2GPR119ALDH1A1 | |
| SCHEMBL5221713 | 0.68 | SPHK1 (0.66) | SPHK1SPHK2KCNH2GPR119ALDH1A1 | |
| SCHEMBL7070577 | 0.68 | SMN1; SMN2 (0.52) | MAOAMAOBKCNH2GPR119ALDH1A1 | |
| SCHEMBL4793698 | 0.68 | KCNH2 (0.39) | CHIT1CHIAKCNH2CHI3L1 | |
| SCHEMBL5225958 | 0.68 | SMN1; SMN2 (0.59) | KCNH2GPR119ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1771449-A1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | Pfizer Products Incorporated (US) | 2007-04-11 | — | — | EP | claimed |
| WO-2006011043-A1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2006-02-02 | — | — | WO | claimed |
| EP-1771449-A1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | Pfizer Products Incorporated (US) | 2007-04-11 | — | — | EP | disclosed |
| WO-2006011043-A1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2006-02-02 | — | — | WO | disclosed |