Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9790 | 0.94 | ALDH1A1 (0.45) | ALDH1A1KDM4EHSD11B1TSHRCA12 | |
| SCHEMBL2417 | 0.94 | ALDH1A1 (0.45) | ALDH1A1KDM4EHSD11B1TSHRCA12 | |
| SCHEMBL2229127 | 0.94 | ALDH1A1 (0.45) | ALDH1A1KDM4EHSD11B1TSHRCA12 | |
| Acetic Acid SCHEMBL1802264 | 0.92 | TERT (0.41) | ALDH1A1KDM4EHSD11B1TSHRCA12 | |
| SCHEMBL21752841 | 0.92 | ALDH1A1 (0.43) | ALDH1A1KDM4EHSD11B1CA12CA1 | |
| SCHEMBL21752879 | 0.92 | ALDH1A1 (0.43) | ALDH1A1KDM4EHSD11B1CA12CA1 | |
| Sulfuric Acid SCHEMBL6545396 | 0.92 | ALDH1A1 (0.43) | ALDH1A1KDM4EHSD11B1CA12CA1 | |
| SCHEMBL21752846 | 0.92 | ALDH1A1 (0.43) | ALDH1A1KDM4EHSD11B1CA12CA1 | |
| SCHEMBL21752843 | 0.92 | ALDH1A1 (0.43) | ALDH1A1KDM4EHSD11B1CA12CA1 | |
| SCHEMBL3365751 | 0.92 | ALDH1A1 (0.43) | ALDH1A1KDM4EHSD11B1CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 381 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118140873-A | Diabetes animal model and construction method and application thereof | 刘丽梅 | 2024-06-07 | — | — | CN | disclosed |
| US-20240182431-A1 | NEW CONTRAST AGENT FOR USE IN MAGNETIC RESONANCE IMAGING | BAYER AKTIENGESELLSCHAFT (DE) | 2024-06-06 | — | — | US | disclosed |
| CN-118048293-A | Vascularized islet organoid and construction method and application thereof | 上海交通大学医学院附属第九人民医院 | 2024-05-17 | — | — | CN | disclosed |
| CN-117904238-A | Fructus cannabis enzymatic hydrolysate and preparation method thereof | 清华大学深圳国际研究生院 | 2024-04-19 | — | — | CN | disclosed |
| CN-117899193-A | Fructus cannabis enzymatic hydrolysate and preparation method thereof | 清华大学深圳国际研究生院 | 2024-04-19 | — | — | CN | disclosed |
| CN-117899141-A | Fructus cannabis enzymatic hydrolysate and preparation method thereof | 清华大学深圳国际研究生院 | 2024-04-19 | — | — | CN | disclosed |
| CN-117903243-A | Fructus cannabis extract polypeptide and application thereof | 清华大学深圳国际研究生院 | 2024-04-19 | — | — | CN | disclosed |
| US-20240115564-A1 | HTR1F ANTAGONISTS FOR IMPROVEMENT OF BETA CELL SURVIVAL AND FUNCTION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2024-04-11 | — | — | US | disclosed |
| WO-2024059954-A1 | THIOL-ENE HYDROGEL | ALLARTA LIFE SCIENCE INC. (CA) | 2024-03-28 | — | — | WO | disclosed |
| WO-2024052573-A1 | COMBINATIONS OF CONTRAST AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 2024-03-14 | — | — | WO | disclosed |
| US-20020137141-A1 | Short peptides from the 'A-region' of protein kinases which selectively modulate protein kinase activity | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2002-09-26 | — | — | US | disclosed |
| US-20020115173-A1 | Short peptides from the 'A-region' of protein kinases which selectively modulate protein kinase activity | CHILDREN'S MEDICAL CENTER CORPORATION | 2002-08-22 | — | — | US | disclosed |
| WO-2002048336-A2 | SHORT PEPTIDES FROM THE 'A-REGION' OF PROTEIN KINASES WHICH SELECTIVELY MODULATE PROTEIN KINASE ACTIVITY | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2002-06-20 | — | — | WO | disclosed |
| EP-1115847-A1 | SHORT PEPTIDES WHICH SELECTIVELY MODULATE THE ACTIVITY OF PROTEIN KINASES | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000018895-A1 | SHORT PEPTIDES WHICH SELECTIVELY MODULATE THE ACTIVITY OF PROTEIN KINASES | THE CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2000-04-06 | — | — | WO | disclosed |
| US-5569581-A | Alteration and prediction of male fertility using seminal plasma and its components | THE PENN STATE RESEARCH FOUNDATION (US) | 1996-10-29 | — | — | US | disclosed |
| EP-0682702-A1 | EXPRESSION OF PROTECTIVE ANTIGENS | Mallinckrodt Veterinary, Inc. (US) | 1995-11-22 | — | — | EP | disclosed |
| WO-1994018320-A1 | EXPRESSION OF PROTECTIVE ANTIGENS | MALLINCKRODT VETERINARY, INC. (US) | 1994-08-18 | — | — | WO | disclosed |
| US-5030637-A | Against senile macular degeneration or diabetic retinopathy | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 1991-07-09 | — | — | US | disclosed |
| US-4971976-A | DIABETIC RETINOPATHY, VISION DEFECTS, PEROXIDATION INHIBITION | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 1990-11-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240115564-A1 | HTR1F ANTAGONISTS FOR IMPROVEMENT OF BETA CELL SURVIVAL AND FUNCTION | HTR1F, HTR1D, HTR1E | ALDH1A1 1175/4885KDM4E 3491/4885HSD11B1 1111/4885 |
| US-20240182431-A1 | NEW CONTRAST AGENT FOR USE IN MAGNETIC RESONANCE IMAGING | MAG, GBA1, GLRX3 | ALDH1A1 3523/4885KDM4E 4186/4885HSD11B1 4852/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.