Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9324260 | 0.76 | IDO1 (0.39) | ALDH1A1L3MBTL1POLBMEN1KMT2A | |
| SCHEMBL19537629 | 0.75 | ALDH1A1 (0.48) | ALDH1A1L3MBTL1TDP1ALOX15POLB | |
| SCHEMBL17073678 | 0.75 | ALDH1A1 (0.48) | ALDH1A1L3MBTL1TDP1ALOX15POLB | |
| SCHEMBL4484831 | 0.69 | PIK3CA (0.43) | ALDH1A1L3MBTL1POLBKMT2AGAA | |
| SCHEMBL4692166 | 0.68 | ALDH1A1 (0.49) | ALDH1A1L3MBTL1TDP1ALOX15POLB | |
| SCHEMBL16363784 | 0.68 | ADORA3 (0.52) | ALDH1A1L3MBTL1TDP1ALOX15POLB | |
| SCHEMBL4840475 | 0.67 | ALDH1A1 (0.42) | ALDH1A1L3MBTL1TDP1ALOX15POLB | |
| SCHEMBL8962457 | 0.67 | ALDH1A1 (0.44) | ALDH1A1L3MBTL1TDP1ALOX15POLB | |
| SCHEMBL6500206 | 0.67 | LRRK2 (0.45) | TDP1ALOX15POLBADORA3SLC6A2 | |
| SCHEMBL22269745 | 0.65 | MAPK8 (0.50) | ALDH1A1ALOX15MAPTMAOACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312203-B2 | 1-aza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof | GlaxoSmithKline istraziva{hacek over (c)}ki Centar Zagreb d.o.o. (HR) | 2007-12-25 | — | — | US | claimed |
| EP-1506202-B1 | 1-AZA-DIBENZOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF | GLAXOSMITHKLINE ZAGREB (HR) | 2007-08-08 | — | — | EP | claimed |
| US-20070111968-A1 | 1-Aza-dibenzo[e,h]azulenes for the treatment of central nervous system diseases and disorders | GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (HR) | 2007-05-17 | — | — | US | claimed |
| US-20050209191-A1 | 1-Aza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof | PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2005-09-22 | — | — | US | claimed |
| US-20050148578-A1 | 1-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the preparation thereof | PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2005-07-07 | — | — | US | claimed |
| US-7312203-B2 | 1-aza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof | GlaxoSmithKline istraziva{hacek over (c)}ki Centar Zagreb d.o.o. (HR) | 2007-12-25 | — | — | US | disclosed |
| EP-1506202-B1 | 1-AZA-DIBENZOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF | GLAXOSMITHKLINE ZAGREB (HR) | 2007-08-08 | — | — | EP | disclosed |
| US-20070111968-A1 | 1-Aza-dibenzo[e,h]azulenes for the treatment of central nervous system diseases and disorders | GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (HR) | 2007-05-17 | — | — | US | disclosed |
| US-20050209191-A1 | 1-Aza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof | PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2005-09-22 | — | — | US | disclosed |
| US-20050148578-A1 | 1-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the preparation thereof | PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2005-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070111968-A1 | 1-Aza-dibenzo[e,h]azulenes for the treatment of central nervous system diseases and disorders | DBH, BCHE, DDT | ALDH1A1 130/4885L3MBTL1 2596/4885TDP1 239/4885 |
| US-20050209191-A1 | 1-Aza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof | TNF, IL1A, IL1B | ALDH1A1 42/4885L3MBTL1 1975/4885TDP1 1577/4885 |
| US-20050148578-A1 | 1-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the preparation thereof | TNF, IL1A, IL1B | ALDH1A1 44/4885L3MBTL1 1949/4885TDP1 1638/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.