Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.45 |
| ▸ | LTK | P29376 | 2/20 | 0.45 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.45 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.45 |
| ▸ | FER | P16591 | 1/20 | 0.45 |
| ▸ | CDK8 | P49336 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 3/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.36 |
| ▸ | RET | P07949 | 2/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.36 |
| ▸ | FLT3 | P36888 | 2/20 | 0.36 |
| ▸ | JAK3 | P52333 | 2/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.36 |
| ▸ | TLK2 | Q86UE8 | 2/20 | 0.36 |
| ▸ | AKT1 | P31749 | 2/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20011699 | 0.81 | LRRK2 (0.36) | LRRK2LTKDYRK1BACVR1PDGFRA | |
| SCHEMBL9324260 | 0.78 | IDO1 (0.39) | MAOAATMMAP2K1MAPTGSK3B | |
| SCHEMBL17816635 | 0.77 | LRRK2 (0.59) | LRRK2LTKDYRK1BACVR1PDGFRA | |
| SCHEMBL181764 | 0.77 | LRRK2 (0.59) | LRRK2LTKDYRK1BACVR1PDGFRA | |
| SCHEMBL30462618 | 0.77 | LRRK2 (0.59) | LRRK2LTKDYRK1BACVR1PDGFRA | |
| SCHEMBL8962457 | 0.68 | ALDH1A1 (0.44) | FYNMAPTCYP1A2POLBCYP3A4 | |
| SCHEMBL2427994 | 0.67 | LRRK2 (0.64) | LRRK2LTKDYRK1BACVR1PDGFRA | |
| SCHEMBL29268797 | 0.67 | ACVR1 (0.48) | LRRK2LTKDYRK1BACVR1PDGFRA | |
| SCHEMBL29268818 | 0.67 | ACVR1 (0.48) | LRRK2LTKDYRK1BACVR1PDGFRA | |
| SCHEMBL22269745 | 0.67 | MAPK8 (0.50) | LRRK2LTKDYRK1BPDGFRACDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050209191-A1 | 1-Aza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof | PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2005-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050209191-A1 | 1-Aza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof | TNF, IL1A, IL1B | LRRK2 4560/4885LTK 1146/4885DYRK1B 3279/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.