Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 3/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TNF | P01375 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.40 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | LOX | P28300 | 1/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18362297 | 0.85 | CNR2 (0.44) | ALDH1A1GAAHSD17B10DRD2ADRA1D | |
| SCHEMBL7049486 | 0.82 | ALDH1A1 (0.46) | ALDH1A1GAAHSD17B10DRD2ADRA1D | |
| SCHEMBL14396060 | 0.82 | ADRA1D (0.41) | ALDH1A1GAAHSD17B10DRD2ADRA1D | |
| SCHEMBL4631885 | 0.81 | CA2 (0.59) | ALDH1A1HTR6 | |
| SCHEMBL7054313 | 0.80 | ALDH1A1 (0.47) | ALDH1A1GAAHSD17B10DRD2ADRA1D | |
| SCHEMBL8233359 | 0.80 | ALDH1A1 (0.47) | ALDH1A1GAAHSD17B10DRD2NPC1 | |
| SCHEMBL568564 | 0.79 | ADH1B (0.52) | ALDH1A1GAAHSD17B10DRD2SMN1; SMN2 | |
| SCHEMBL27626636 | 0.79 | ALDH1A1 (0.48) | ALDH1A1GAAHSD17B10DRD2ADRA1D | |
| SCHEMBL14406750 | 0.78 | ALDH1A1 (0.46) | ALDH1A1GAAHSD17B10DRD2ADRA1D | |
| SCHEMBL1127911 | 0.78 | HTR6 (0.51) | ALDH1A1GAAHSD17B10DRD2GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869055-A1 | NOVEL 5,7-DISUBSTITUTED Ý1,3¨THIAZOLOÝ4,5-D¨PYRIMIDIN-2(3H)-ONE DERIVATIVES | AstraZeneca AB (SE) | 2007-12-26 | — | — | EP | disclosed |
| EP-1869056-A1 | NOVEL 5-SUBSTITUTED 7-AMINO-Ý1,3¨THIAZOLOÝ4,5-D¨PYRIMIDINE DERIVATIVES | AstraZeneca AB (SE) | 2007-12-26 | — | — | EP | disclosed |
| WO-2006107258-A1 | NOVEL 5-SUBSTITUTED 7-AMINO-[1,3]THIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2006-10-12 | — | — | WO | disclosed |
| WO-2006107257-A1 | NOVEL 5,7-DISUBSTITUTED [1,3]THIAZOLO[4,5-D]PYRIMIDIN-2(3H)-ONE DERIVATIVES | ASTRAZENECA AB (SE) | 2006-10-12 | — | — | WO | disclosed |