Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 2/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.33 |
| ▸ | P4HB | P07237 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5907357 | 0.86 | HTR1A (0.39) | HTR7OPRK1LMNAKMT2AHTR1A | |
| SCHEMBL5228031 | 0.84 | MAPK1 (0.40) | HTR7OPRK1KCNH2PSEN1PSEN2 | |
| SCHEMBL2001557 | 0.80 | KCNH2 (0.37) | KMT2AKCNH2PSEN1PSEN2APH1B | |
| SCHEMBL7256613 | 0.80 | HTR1A (0.40) | HTR7OPRK1LMNAKMT2AKCNH2 | |
| SCHEMBL5225734 | 0.79 | GPR55 (0.39) | — | |
| SCHEMBL2001021 | 0.79 | LMNA (0.33) | LMNAKCNH2PSEN1PSEN2APH1B | |
| SCHEMBL2000118 | 0.74 | KCNH2 (0.33) | HTR7LMNAKCNH2PSEN1PSEN2 | |
| SCHEMBL2003026 | 0.73 | GSK3B (0.33) | HTR7LMNAMAPK14HTR1AHTR2B | |
| SCHEMBL1999526 | 0.73 | ROCK2 (0.39) | OPRK1KMT2AACHEKCNH2P4HB | |
| SCHEMBL5907264 | 0.72 | CNR2 (0.41) | HTR7ACHEHRH3P4HBHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1611122-B1 | SUBSTITUTED PYRAZOLE COMPOUNDS | MERCK PATENT GMBH (DE) | 2007-06-13 | — | — | EP | disclosed |