Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 3/20 | 0.47 |
| ▸ | DRD3 | P35462 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 8/20 | 0.47 |
| ▸ | SMO | Q99835 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5228465 | 0.91 | SMO (0.46) | DRD4DRD3MAPTSMOKDM4E | |
| SCHEMBL1997979 | 0.83 | SMO (0.60) | DRD4DRD3MAPTSMOALDH1A1 | |
| SCHEMBL5224322 | 0.82 | ALDH1A1 (0.51) | DRD4DRD3MAPTKDM4EALDH1A1 | |
| SCHEMBL5228219 | 0.80 | SMO (0.47) | DRD4DRD3MAPTSMOALDH1A1 | |
| SCHEMBL10360539 | 0.79 | SMO (0.64) | DRD4DRD3MAPTSMOKDM4E | |
| SCHEMBL5737789 | 0.79 | SMO (0.44) | DRD4DRD3MAPTSMOALDH1A1 | |
| SCHEMBL5228124 | 0.79 | SMO (0.43) | DRD4DRD3MAPTSMOLMNA | |
| SCHEMBL5227160 | 0.78 | SMO (0.41) | DRD4DRD3MAPTSMOKDM4E | |
| SCHEMBL2761009 | 0.78 | SMO (0.43) | DRD4DRD3MAPTSMOALDH1A1 | |
| SCHEMBL5226795 | 0.77 | SMO (0.42) | DRD4DRD3MAPTSMOKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1611122-B1 | SUBSTITUTED PYRAZOLE COMPOUNDS | MERCK PATENT GMBH (DE) | 2007-06-13 | — | — | EP | disclosed |