Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 3/20 | 0.41 |
| ▸ | DRD4 | P21917 | 3/20 | 0.41 |
| ▸ | DRD3 | P35462 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MELK | Q14680 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 6/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 6/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 6/20 | 0.40 |
| ▸ | HRH2 | P25021 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5226795 | 0.87 | SMO (0.42) | SMODRD2DRD4DRD3MAPT | |
| SCHEMBL5225922 | 0.87 | L3MBTL1 (0.53) | SMOMAPTLMNAL3MBTL1 | |
| SCHEMBL5228638 | 0.85 | DRD4 (0.41) | SMODRD2DRD4DRD3MAPT | |
| SCHEMBL5227160 | 0.84 | SMO (0.41) | SMODRD2DRD4DRD3MAPT | |
| SCHEMBL5228219 | 0.83 | SMO (0.47) | SMODRD2DRD4DRD3MAPT | |
| SCHEMBL5737789 | 0.83 | SMO (0.44) | SMODRD2DRD4DRD3MAPT | |
| SCHEMBL1997979 | 0.82 | SMO (0.60) | SMODRD2DRD4DRD3MAPT | |
| SCHEMBL5230174 | 0.82 | DRD4 (0.46) | SMODRD2DRD4DRD3MAPT | |
| SCHEMBL2761009 | 0.81 | SMO (0.43) | SMODRD2DRD4DRD3MAPT | |
| SCHEMBL5226797 | 0.81 | SMO (0.61) | SMOMAPTMAPK14LMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1611122-B1 | SUBSTITUTED PYRAZOLE COMPOUNDS | MERCK PATENT GMBH (DE) | 2007-06-13 | — | — | EP | disclosed |