Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | DRD4 | P21917 | 4/20 | 0.38 |
| ▸ | DRD3 | P35462 | 4/20 | 0.38 |
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | MPO | P05164 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | FLT4 | P35916 | 1/20 | 0.36 |
| ▸ | TEK | Q02763 | 1/20 | 0.36 |
| ▸ | CHKA | P35790 | 2/20 | 0.36 |
| ▸ | MC4R | P32245 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5226383 | 0.87 | DRD3 (0.44) | SMODRD4DRD3DRD2TNIK | |
| SCHEMBL5228124 | 0.87 | SMO (0.43) | SMOMAPTDRD4DRD3DRD2 | |
| SCHEMBL5232121 | 0.85 | DRD4 (0.39) | SMOMAPTDRD4DRD3DRD2 | |
| SCHEMBL5225922 | 0.83 | L3MBTL1 (0.53) | SMOMAPTL3MBTL1LMNAALDH1A1 | |
| SCHEMBL5227160 | 0.82 | SMO (0.41) | SMOMAPTDRD4DRD3DRD2 | |
| SCHEMBL5228219 | 0.82 | SMO (0.47) | SMOMAPTDRD4DRD3DRD2 | |
| SCHEMBL5737789 | 0.81 | SMO (0.44) | SMOMAPTDRD4DRD3DRD2 | |
| SCHEMBL1997979 | 0.81 | SMO (0.60) | SMOMAPTDRD4DRD3DRD2 | |
| SCHEMBL5230174 | 0.81 | DRD4 (0.46) | SMOMAPTDRD4DRD3DRD2 | |
| SCHEMBL2761009 | 0.79 | SMO (0.43) | SMOMAPTDRD4DRD3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1611122-B1 | SUBSTITUTED PYRAZOLE COMPOUNDS | MERCK PATENT GMBH (DE) | 2007-06-13 | — | — | EP | disclosed |